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• W825775564 abstract "AbstractThe Effect of Li Zhong Tang on the Suppression of Th2 Differentiation by IFN-γ Response in IgE Hyperproduction and Atopic Dermatitis-like Skin Lesions Induced NC/Nga Mouse Seo Hui Yeon, Han Jae Kyung, Kim Yun HeeDepartment of Pediatrics, College of Oriental Medicine, Daejeon University ObjectivesThe purpose of this study is to investigate the effect of Li Zhong Tang(LZH-T) on atopic dermatitis by using NC/Nga atopic dermatitis mouse. MethodsFirst, in vitro, we isolated B cells from NC/Nga mouse which induced atopic dermatitis-like skin for 18 weeks. We analyzed FACS by intracellular staining of IFN-γ, GATA-3+ and also analyzed cytokines by using real-time PCR. Secondly, in vivo, after administration of LZH-T to the 12 weeks old mouse with atopic dermatitis. We analyzed serum IgE, IFN-γ level and observed the changes of activated cell. ResultsIn vitro, LZH-T decreased the levels of CD4+/IFN-γ+ and increased the levels of CD4+/GATA3+.In vivo, serum IgE levels were decreased and IFN-γ levels were increased in LZH-T group compared to the control group. In PBMCs, the percentage of activated cell - granulocytes, CD3+, CD3+CD4+, B220+CD23+, and CCR3+ were decreased and CD19+, CD3+CD8+ were increased in LZH-T group compared to the control group.ConclusionsThis study demonstrates immunological activity of GPJST on atopic dermatitis-like model mice.Key words： Atopic dermatitis, Li Zhong Tang, NC/Nga mouse" @default.
• W825775564 created "2016-06-24" @default.
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• W825775564 date "2009-01-01" @default.
• W825775564 modified "2023-09-24" @default.
• W825775564 title "The Effect of Li Zhong Tang on the Suppression of Th2 Differentiation by IFN-γ Response in IgE Hyperproduction and Atopic Dermatitis-like Skin Lesions Induced NC/Nga Mouse" @default.
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