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- W82584802 abstract "Fish perceive water-soluble chemicals at the taste buds that are distributed on oropharyngeal and trunk epithelia. Recent progress in molecular analyses has revealed that teleosts and mammals share pivotal signaling components to transduce taste stimuli. The fish orthologs of taste receptors, fT1R and fT2R, show mutually exclusive expression in taste buds, and both are coexpressed with phospholipase C-β2 and the transient receptor potential M5 channel as common downstream components of taste receptor signals. Interestingly, fT1R heteromers are activated by various l-amino acids but not by sugars. This may reflects that in fish the energy metabolism depends primarily on gluconeogenesis from amino acids. fT2Rs are activated by denatonium benzoate, which is a bitter substance for mammals. It is thus likely that the preferable and aversive tastes for vertebrates, though their taste modalities somewhat vary, are transduced by the sensory conserved pathways. The comparative molecular biology of the fish taste system would lead to understanding a general logic of encoding taste modalities in vertebrates." @default.
- W82584802 created "2016-06-24" @default.
- W82584802 creator A5004388848 @default.
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- W82584802 date "2009-01-01" @default.
- W82584802 modified "2023-10-16" @default.
- W82584802 title "Gustation in Fish: Search for Prototype of Taste Perception" @default.
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- W82584802 doi "https://doi.org/10.1007/400_2008_6" @default.
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