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- W82661716 abstract "Background: Experimental evidence suggests that xanthine oxidase inhibitors (XOIs) can somehow reduce myocardial oxygen consumption for a given stroke volume. If such an effect also occurred in man, the possibility arises that XOIs could become a new anti-ischaemic agent in angina pectoris. Aim: To investigate if allopurinol has anti-ischaemic effects in chronic stable angina Methods: Sixty-five patients with stable chronic angina pectoris were recruited for a double blind, randomised, placebo controlled crossover study. They were randomised to receive either allopurinol (600 mg/day) or placebo for 6 weeks and then crossed over. Prior to randomisation and at the end of each treatment period, patients underwent an exercise tolerance test. Results: Allopurinol significantly increased total exercise time, time to ST depression and time to symptoms compared to placebo (see table 1). In addition, the systolic blood pressure at the end of the first stage of the Bruce protocol was significantly lower in the allopurinol arm (−6.1 mmHg) compared to placebo (−1.6 mmHg) (p=0.026). A higher heart rate and rate pressure product was achieved at peak exercise in the allopurinol arm compared to placebo. Conclusion: In stable angina pectoris, high dose allopurinol has anti-ischaemic properties. Further research is needed to define the best place for high dose allopurinol in the overall management of angina pectoris." @default.
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- W82661716 date "2009-11-03" @default.
- W82661716 modified "2023-09-24" @default.
- W82661716 title "Abstract 4517: High Dose Allopurinol is Anti-Ischaemic in Chronic Stable Angina" @default.
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