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- W82673774 abstract "A new, general approach to the synthesis of 2-thiohydantoins from protected α-amino acid derivatives is now available, which allows the synthesis of sensitive thiohydantoins. A solid phase development system (SPDS) has also been established to facilitate comprehensive studies of C-terminal chemistries. Peptides are attached via their amino groups, and may be detached to perform subsequent analyses. In this way, the fate of the peptide portion may be determined after exposure to various reaction conditions. Here we report the application of these tools in C-terminal sequencing studies using a new reagent benzoyl isothiocyanate (BITC). Coupling and cleavage chemistry are conveniently monitored in the SPDS. Reasonably efficient sequencing of a simple peptide is shown." @default.
- W82673774 created "2016-06-24" @default.
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- W82673774 date "1991-01-01" @default.
- W82673774 modified "2023-10-13" @default.
- W82673774 title "Chemical C-Terminal Sequencing" @default.
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- W82673774 doi "https://doi.org/10.1007/978-3-0348-5678-2_3" @default.
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