Matches in SemOpenAlex for { <https://semopenalex.org/work/W8272635> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W8272635 endingPage "36" @default.
- W8272635 startingPage "329" @default.
- W8272635 abstract "It was shown for the first time that p-aminobenzoic acid (PABA), in addition to the previously described fibrinolytic activity, exerts the properties of a direct anticoagulant both in vitro and in vivo. PABA not only displays antithrombin activity, but also inhibits activated factor X and, upon intravenous injection to rats and rabbits, shows the antithrombotic effect. The most pronounced antithrombotic affect was observed at a dose of 1.5 mg/kg. PABA at 0.5 mg/kg has insignificant efficacy and at 3 mg/kg, a high efficacy, but induces hemolysis of erythrocytes in about a half of cases. Equally efficient antithrombotic activity of blood plasma of rats was noted after intravenous injection of low molecular weight heparin Fraxiparin at 40 anti-Xa U/kg and PABA at 25 anti-Xa U/kg (1.5 mg/kg). Unlike Fraxiparin, which exerts an immediate effect, the effect of PABA was expressed within 1.5 to 5 h after injection with a peak of antithrombotic activity at 3 h (which correlates with anti-IIa and anti-Xa activities of plasma) and terminated by 5 h after injection. For PABA, the ratio of anti-Xa to anti-IIa activities (an important parameter, which determines the antithrombotic potential of drugs) equals 2.4. PABA at 0.5 or 1.5 mg/kg did not affect the number of thrombocytes, while at 3 mg/kg, it decreased the number of thrombocytes by 20%. Thus PABA at 1.5 mg/kg, which has a high anticoagulant activity and does not cause side effects, is most interesting for further studies." @default.
- W8272635 created "2016-06-24" @default.
- W8272635 creator A5016733184 @default.
- W8272635 creator A5020908691 @default.
- W8272635 creator A5022020567 @default.
- W8272635 creator A5051199821 @default.
- W8272635 creator A5059636172 @default.
- W8272635 creator A5076148991 @default.
- W8272635 date "1999-08-12" @default.
- W8272635 modified "2023-09-26" @default.
- W8272635 title "[The antithrombotic activity of para-aminobenzoic acid in experimental thrombosis]." @default.
- W8272635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10441911" @default.
- W8272635 hasPublicationYear "1999" @default.
- W8272635 type Work @default.
- W8272635 sameAs 8272635 @default.
- W8272635 citedByCount "1" @default.
- W8272635 countsByYear W82726352018 @default.
- W8272635 crossrefType "journal-article" @default.
- W8272635 hasAuthorship W8272635A5016733184 @default.
- W8272635 hasAuthorship W8272635A5020908691 @default.
- W8272635 hasAuthorship W8272635A5022020567 @default.
- W8272635 hasAuthorship W8272635A5051199821 @default.
- W8272635 hasAuthorship W8272635A5059636172 @default.
- W8272635 hasAuthorship W8272635A5076148991 @default.
- W8272635 hasConcept C126322002 @default.
- W8272635 hasConcept C150903083 @default.
- W8272635 hasConcept C185592680 @default.
- W8272635 hasConcept C203014093 @default.
- W8272635 hasConcept C207001950 @default.
- W8272635 hasConcept C2777015399 @default.
- W8272635 hasConcept C2777557582 @default.
- W8272635 hasConcept C2778205648 @default.
- W8272635 hasConcept C2779026020 @default.
- W8272635 hasConcept C2779902561 @default.
- W8272635 hasConcept C55493867 @default.
- W8272635 hasConcept C71924100 @default.
- W8272635 hasConcept C86803240 @default.
- W8272635 hasConcept C89560881 @default.
- W8272635 hasConcept C98274493 @default.
- W8272635 hasConceptScore W8272635C126322002 @default.
- W8272635 hasConceptScore W8272635C150903083 @default.
- W8272635 hasConceptScore W8272635C185592680 @default.
- W8272635 hasConceptScore W8272635C203014093 @default.
- W8272635 hasConceptScore W8272635C207001950 @default.
- W8272635 hasConceptScore W8272635C2777015399 @default.
- W8272635 hasConceptScore W8272635C2777557582 @default.
- W8272635 hasConceptScore W8272635C2778205648 @default.
- W8272635 hasConceptScore W8272635C2779026020 @default.
- W8272635 hasConceptScore W8272635C2779902561 @default.
- W8272635 hasConceptScore W8272635C55493867 @default.
- W8272635 hasConceptScore W8272635C71924100 @default.
- W8272635 hasConceptScore W8272635C86803240 @default.
- W8272635 hasConceptScore W8272635C89560881 @default.
- W8272635 hasConceptScore W8272635C98274493 @default.
- W8272635 hasIssue "3" @default.
- W8272635 hasLocation W82726351 @default.
- W8272635 hasOpenAccess W8272635 @default.
- W8272635 hasPrimaryLocation W82726351 @default.
- W8272635 hasRelatedWork W2005671120 @default.
- W8272635 hasRelatedWork W2069182602 @default.
- W8272635 hasRelatedWork W2094940976 @default.
- W8272635 hasRelatedWork W2105503846 @default.
- W8272635 hasRelatedWork W2141477615 @default.
- W8272635 hasRelatedWork W2410478899 @default.
- W8272635 hasRelatedWork W2441379086 @default.
- W8272635 hasRelatedWork W2533206134 @default.
- W8272635 hasRelatedWork W3166840840 @default.
- W8272635 hasRelatedWork W8272635 @default.
- W8272635 isParatext "false" @default.
- W8272635 isRetracted "false" @default.
- W8272635 magId "8272635" @default.
- W8272635 workType "article" @default.