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- W8279900 abstract "Although the field of receptor-activated Ca 2+ entry has been dominated by the concept of store-operated entry, and despite the widespread presence of such pathways in cells, studies have shown that alternative store-independent pathways of Ca 2+ entry may predominate at low, physiologically relevant, levels of stimulation. The Arachidonic acid regulated Ca 2+ (ARC) channels represent the most thoroughly characterized of these store-independent pathways. ARC channels are a highly Ca 2+ -selective conductance whose activation is specifically mediated by low levels of receptor-generated arachidonic acid. Interestingly, recent studies on the molecular bases of their structure and regulation have revealed close relationships with the classic store-operated CRAC channels, including the involvement of members of the Orai family of proteins in the formation of the channel pore, and the dependence on STIM1 for their activation. However, the Orai protein composition and stoichiometry of these channels is entirely distinct, as is the pool of STIM1 responsible for their activation. Physiologically, several studies have shown that the ARC channels serve unique and important functions in cells, including the modulation of the frequency of Ca 2+ oscillations at low agonist concentrations, providing the predominant source of Ca 2+ entry necessary for pancreatic exocrine secretion and contributing to the secretagog-stimulated release of insulin in pancreatic β cells." @default.
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- W8279900 date "2013-01-01" @default.
- W8279900 modified "2023-09-26" @default.
- W8279900 title "Arachidonic Acid Regulated Calcium Channel" @default.
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- W8279900 doi "https://doi.org/10.1016/b978-0-12-378630-2.00196-1" @default.
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