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- W82815815 abstract "Abstract AAntibodies secreted by terminally differentiated plasma cells are important in immune defense, but also contribute to the pathogenesis of autoimmune diseases. How do naïve and memory B cells efficiently and promptly undergo terminal differentiation after encountering an antigen remains to be fully understood. We found that in the human tonsil most CD138+ plasma cells are surrounded by CD163+ resident macrophages. This prompted us to explore the role of macrophages in B cell activation. Sorted tonsilar macrophages were co-cultured with autologous IgD+CD27- naïve B or IgD-CD27+ memory B cells that were activated by anti-Ig, CpG and IL-2. Both naïve and memory B cells co-cultured with macrophages underwent significant proliferation and differentiation towards CD138+CD38+ plasma cells, whereas B cells alone failed to do so. A similar finding was obtained by using in vitro-generated macrophages. Such a process was tightly regulated by the dominant production of IP-10 by macrophages and the receptor CXCR3 on B cells. We found that patients with systemic lupus erythematosus (SLE) with active disease display an expansion of CXCR3+ B cells (range 20-90%) compared to those with inactive disease (range 5-15%). Accordingly, serum levels of IP-10 were elevated in active SLE patients. Thus, our data support a previously unrecognized mechanism by which macrophages induce terminal differentiation of plasma cells through secretion of IP-10, which may have potential implications autoimmunity." @default.
- W82815815 created "2016-06-24" @default.
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- W82815815 date "2010-04-01" @default.
- W82815815 modified "2023-09-25" @default.
- W82815815 title "IP-10-dependent terminal differentiation of human plasma cells: an implication for autoimmunity (135.5)" @default.
- W82815815 doi "https://doi.org/10.4049/jimmunol.184.supp.135.5" @default.
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