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- W82868488 abstract "Voltage-dependent {sup 45}Ca{sup 2+} uptake into rat whole brain P1 (nonsynaptosomal) and P2 (synaptosomal) fractions was measured after 60-s KCl-stimulated depolarization to investigate possible inhibitory effects of Ca{sup 2+} antagonists, nitrendipine, diltiazem, verapamil and ifenprodil tartrate. All drugs (10(-5)M) had little influence on {sup 45}Ca{sup 2+} uptake by whole brain P1 fraction in both nondepolarizing and depolarizing mediums. Diltiazem (10(-5)M) had no influence on {sup 45}Ca{sup 2+} uptake by whole brain P2 fraction under both conditions. However, nitrendipine (10(-5)M) verapamil (10(-5)M) and ifenprodil tartrate inhibited depolarization-dependent {sup 45}Ca{sup 2+} uptake by whole brain P2 fraction, while nondepolarization-dependent {sup 45}Ca{sup 2+} uptake was not affected by these drugs. The inhibitory sequence of depolarization-dependent {sup 45}Ca{sup 2+} uptake by P2 fraction was: ifenprodil tartrate greater than nitrendipine greater than verapamil. These results suggest that ifenprodil tartrate, nitrendipine and verapamil specifically inhibit depolarization-dependent synaptosomal {sup 45}Ca{sup 2+} uptake, but that diltiazem has little influence on it." @default.
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- W82868488 date "1989-06-01" @default.
- W82868488 modified "2023-09-24" @default.
- W82868488 title "Effects of Ca sup 2+ antagonists on sup 45 Ca sup 2+ uptake by rat whole brain P1 and P2 fractions" @default.
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