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- W82954253 abstract "This chapter discusses the rationale for utilizing recombinant DNA-technology in the production of insulin. It describes the procedures used to prepare highly purified human insulin and the analytical tests demonstrating that human insulin produced using recombinant DNA technology is of high purity and safe for use in humans. Insulin is an anti-diabetic hormone produced in the pancreas by s-cells of the islets of Langerhans. Insulin from bovine—derived from the cow—and insulin from porcine—derived from the pig pancreata—have been used extensively in the treatment of diabetes mellitus. Plasmid pBR322 is used extensively in genetic engineering. It has two genes of special interest. One codes for a protein that enables any host bacterium to resist the lethal effects of the antibiotic ampicillin and the other confers resistance to tetracycline. The other gene contains a sequence of six bases recognized by the restriction enzyme Bam H1. The chapter describes a case study with a survey of the clinical studies carried out with human insulin produced using recombinant DNA technology." @default.
- W82954253 created "2016-06-24" @default.
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- W82954253 date "1991-01-01" @default.
- W82954253 modified "2023-10-16" @default.
- W82954253 title "Case Study: Human insulin of rDNA origin" @default.
- W82954253 doi "https://doi.org/10.1016/b978-0-7506-1497-9.50011-8" @default.
- W82954253 hasPublicationYear "1991" @default.
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