Matches in SemOpenAlex for { <https://semopenalex.org/work/W829806972> ?p ?o ?g. }
- W829806972 abstract "Beginning with the development of an embryo and throughout one’s adult life angiogenesis plays an essential role for organ growth and repair. The balancing of proangiogenic factors to anti-angiogenic factors is what regulates the process of angiogenesis. When this balance is disrupted in one direction or the other, numerous disorders can occur including ocular and inflammatory diseases and, in particular, tumor growth and metastasis. Therefore, inhibition of angiogenesis has become an effective therapy for arresting the growth of tumors. A key regulator of angiogenesis involves vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (KDR). The binding of VEGF to KDR activates the receptor which, in turn, initiates the signaling cascade leading to cell proliferation, migration, and survival. The extracellular portion of KDR consists of seven Ig-like domains (Ig1-7), in which Ig1-3 is believed to be responsible for the ligand binding and Ig4-7 for receptor dimerization. We hypothesized that a soluble fragment of the KDR extracellular domain (KDR-Ig4-7) that lacks a tyrosine kinase domain may serve as a KDR antagonist by binding to the membrane bound KDR to form a KDR dimer thus preventing VEGF induced signal transduction. In this study various KDR proteins (KDR-Ig4-7, KDR-Ig4-6, KDR-Ig5-7 and KDR-Ig5-6) were produced, purified and characterized for their potential anti-angiogenic ability. We demonstrated that KDR-Ig4-7 was able to specifically bind to human umbilical vein endothelial cells (HUVEC), and accumulated specifically in tumors indicating its ability to target endothelial cells. Furthermore, KDR-Ig4-7 was able to" @default.
- W829806972 created "2016-06-24" @default.
- W829806972 creator A5026424090 @default.
- W829806972 date "2007-01-01" @default.
- W829806972 modified "2023-09-23" @default.
- W829806972 title "Characterization of the Anti-angiogenic Properties of KDR-Ig4-7 and its Variants as Potential Anti-cancer Therapeutics" @default.
- W829806972 cites W1489873347 @default.
- W829806972 cites W1494571575 @default.
- W829806972 cites W1502515987 @default.
- W829806972 cites W1531079490 @default.
- W829806972 cites W1570971207 @default.
- W829806972 cites W1579297325 @default.
- W829806972 cites W1593130318 @default.
- W829806972 cites W1670891845 @default.
- W829806972 cites W1679229092 @default.
- W829806972 cites W1756894428 @default.
- W829806972 cites W1845506541 @default.
- W829806972 cites W1863396779 @default.
- W829806972 cites W1963876488 @default.
- W829806972 cites W1964389139 @default.
- W829806972 cites W1966091070 @default.
- W829806972 cites W1966535797 @default.
- W829806972 cites W1966931906 @default.
- W829806972 cites W1967587727 @default.
- W829806972 cites W1969695473 @default.
- W829806972 cites W1970614272 @default.
- W829806972 cites W1973918329 @default.
- W829806972 cites W1974188350 @default.
- W829806972 cites W1977776349 @default.
- W829806972 cites W1978139448 @default.
- W829806972 cites W1978340181 @default.
- W829806972 cites W1980701140 @default.
- W829806972 cites W1982246723 @default.
- W829806972 cites W1982912692 @default.
- W829806972 cites W1985359220 @default.
- W829806972 cites W1985712533 @default.
- W829806972 cites W1986412618 @default.
- W829806972 cites W1986559037 @default.
- W829806972 cites W1987306181 @default.
- W829806972 cites W1987454669 @default.
- W829806972 cites W1990624032 @default.
- W829806972 cites W1991123816 @default.
- W829806972 cites W1991958278 @default.
- W829806972 cites W1992101966 @default.
- W829806972 cites W1995857537 @default.
- W829806972 cites W1997254182 @default.
- W829806972 cites W1999600810 @default.
- W829806972 cites W2000064849 @default.
- W829806972 cites W2000196730 @default.
- W829806972 cites W2000292756 @default.
- W829806972 cites W2000307014 @default.
- W829806972 cites W2001658518 @default.
- W829806972 cites W2002408287 @default.
- W829806972 cites W2003686790 @default.
- W829806972 cites W2004907588 @default.
- W829806972 cites W2004918005 @default.
- W829806972 cites W2005994924 @default.
- W829806972 cites W2008786326 @default.
- W829806972 cites W2008830445 @default.
- W829806972 cites W2009968499 @default.
- W829806972 cites W2009997132 @default.
- W829806972 cites W2010092400 @default.
- W829806972 cites W2012607934 @default.
- W829806972 cites W2013041233 @default.
- W829806972 cites W2013818100 @default.
- W829806972 cites W2014133561 @default.
- W829806972 cites W2019426369 @default.
- W829806972 cites W2022163230 @default.
- W829806972 cites W2023052504 @default.
- W829806972 cites W2025173623 @default.
- W829806972 cites W2025600570 @default.
- W829806972 cites W2025933554 @default.
- W829806972 cites W2026038921 @default.
- W829806972 cites W2029521699 @default.
- W829806972 cites W2031061373 @default.
- W829806972 cites W2033759107 @default.
- W829806972 cites W2034269086 @default.
- W829806972 cites W2034448175 @default.
- W829806972 cites W2035127867 @default.
- W829806972 cites W2035595755 @default.
- W829806972 cites W2035693645 @default.
- W829806972 cites W2040972148 @default.
- W829806972 cites W2041323282 @default.
- W829806972 cites W2041609936 @default.
- W829806972 cites W2041816417 @default.
- W829806972 cites W2043508733 @default.
- W829806972 cites W2045247659 @default.
- W829806972 cites W2046516822 @default.
- W829806972 cites W2047470479 @default.
- W829806972 cites W2048141128 @default.
- W829806972 cites W2049612319 @default.
- W829806972 cites W2049852228 @default.
- W829806972 cites W2050499474 @default.
- W829806972 cites W2053221827 @default.
- W829806972 cites W2053473403 @default.
- W829806972 cites W2054154416 @default.
- W829806972 cites W2054979979 @default.
- W829806972 cites W2055515174 @default.
- W829806972 cites W2058268622 @default.
- W829806972 cites W2060118799 @default.