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- W83019651 abstract "Arachidonyl ethanolamide (anandamide, AEA) is an endogenously produced lipid amide which binds to and activates the CB1 and CB2 cannabinoid receptors. Further, administration of arachidonyl ethanolamide to animals produces many of the same physiological effects as classical and non-classical cannabinoids1,2. The CB1 cannabinoid receptors are found in the brain and central nervous system; the CB2 cannabinoid receptors are found in immune cells and tissue. Because arachidonyl ethanolamide is an arachidonic acid derivative, it is possible that it may be metabolized to a prostaglandin derivative. The carboxylic acid moiety is not necessary for binding to cyclooyxgenase, the enzyme which begins the arachidonic acid cascade3,4, suggesting that an ethanol amide derivative might be possible as a substrate for this enzyme. This lends potential physiological relevance to a prostaglandin amide." @default.
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- W83019651 date "1999-01-01" @default.
- W83019651 modified "2023-10-14" @default.
- W83019651 title "Investigation of Structural Analogs of Prostaglandin Amides for Binding to and Activation of CB1 and CB2 Cannabinoid Receptors in Rat Brain and Human Tonsils" @default.
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- W83019651 doi "https://doi.org/10.1007/978-1-4615-4793-8_77" @default.
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