Matches in SemOpenAlex for { <https://semopenalex.org/work/W830226309> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W830226309 endingPage "96" @default.
- W830226309 startingPage "78" @default.
- W830226309 abstract "Aberrant protein glycosylation is involved in many diseases including cancer. This study investigated the role of fucosyltransferase VII (FUT7) in the progression of follicular thyroid carcinoma (FTC). FUT7 expression was found to be upregulated in FTC compared to paracancerous thyroid tissue, and in FTC with T2 stage of TMN classification compared to FTC with T1 stage. FUT7 overexpression promoted cell proliferation, epithelial–mesenchymal transition (EMT), and the migration and invasion of primary FTC cell line FTC-133. Consistently, FUT7 knock-down inhibited cell proliferation, EMT, as well as the migration and invasion of the metastatic FTC cell line FTC-238. Mechanistic investigation revealed that FUT7 catalyzed the α1,3-fucosylation of epidermal growth factor receptor (EGFR) in FTC cells. The extent of glycan α1,3-fucosylation on EGFR was positively correlated with the activation of EGFR in the presence/absence of epidermal growth factor (EGF) treatment. Furthermore, FUT7 was shown to enhance EGF-induced progression of FTC cells through mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathways. These findings provide a new perspective on FUT7 that may be a novel diagnostic and therapeutic target of FTC." @default.
- W830226309 created "2016-06-24" @default.
- W830226309 creator A5022683524 @default.
- W830226309 date "1958-01-01" @default.
- W830226309 modified "2023-09-27" @default.
- W830226309 title "NEW OBSERVATIONS ON BIOCHEMICAL INTERACTIONS BETWEEN NUCLEUS AND CYTOPLASM IN AMOEBA AND ACETABULARIA" @default.
- W830226309 cites W1591030639 @default.
- W830226309 cites W1963597960 @default.
- W830226309 cites W1974377406 @default.
- W830226309 cites W1974401409 @default.
- W830226309 cites W1978212129 @default.
- W830226309 cites W1980403093 @default.
- W830226309 cites W1982067613 @default.
- W830226309 cites W1982478809 @default.
- W830226309 cites W1984182574 @default.
- W830226309 cites W1985821804 @default.
- W830226309 cites W1988832687 @default.
- W830226309 cites W1995406567 @default.
- W830226309 cites W2005210837 @default.
- W830226309 cites W200986768 @default.
- W830226309 cites W2009944304 @default.
- W830226309 cites W2044938036 @default.
- W830226309 cites W2048545366 @default.
- W830226309 cites W2070778702 @default.
- W830226309 cites W2091165578 @default.
- W830226309 cites W2146212977 @default.
- W830226309 cites W2196704366 @default.
- W830226309 cites W2222006317 @default.
- W830226309 doi "https://doi.org/10.1016/s0014-4827(21)00274-3" @default.
- W830226309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13803665" @default.
- W830226309 hasPublicationYear "1958" @default.
- W830226309 type Work @default.
- W830226309 sameAs 830226309 @default.
- W830226309 citedByCount "39" @default.
- W830226309 crossrefType "journal-article" @default.
- W830226309 hasAuthorship W830226309A5022683524 @default.
- W830226309 hasConcept C108625454 @default.
- W830226309 hasConcept C153911025 @default.
- W830226309 hasConcept C170493617 @default.
- W830226309 hasConcept C184235292 @default.
- W830226309 hasConcept C206212055 @default.
- W830226309 hasConcept C2776362946 @default.
- W830226309 hasConcept C2779212266 @default.
- W830226309 hasConcept C2779438470 @default.
- W830226309 hasConcept C502942594 @default.
- W830226309 hasConcept C54355233 @default.
- W830226309 hasConcept C55493867 @default.
- W830226309 hasConcept C57074206 @default.
- W830226309 hasConcept C62478195 @default.
- W830226309 hasConcept C75217442 @default.
- W830226309 hasConcept C81885089 @default.
- W830226309 hasConcept C86554907 @default.
- W830226309 hasConcept C86803240 @default.
- W830226309 hasConcept C95444343 @default.
- W830226309 hasConcept C97029542 @default.
- W830226309 hasConceptScore W830226309C108625454 @default.
- W830226309 hasConceptScore W830226309C153911025 @default.
- W830226309 hasConceptScore W830226309C170493617 @default.
- W830226309 hasConceptScore W830226309C184235292 @default.
- W830226309 hasConceptScore W830226309C206212055 @default.
- W830226309 hasConceptScore W830226309C2776362946 @default.
- W830226309 hasConceptScore W830226309C2779212266 @default.
- W830226309 hasConceptScore W830226309C2779438470 @default.
- W830226309 hasConceptScore W830226309C502942594 @default.
- W830226309 hasConceptScore W830226309C54355233 @default.
- W830226309 hasConceptScore W830226309C55493867 @default.
- W830226309 hasConceptScore W830226309C57074206 @default.
- W830226309 hasConceptScore W830226309C62478195 @default.
- W830226309 hasConceptScore W830226309C75217442 @default.
- W830226309 hasConceptScore W830226309C81885089 @default.
- W830226309 hasConceptScore W830226309C86554907 @default.
- W830226309 hasConceptScore W830226309C86803240 @default.
- W830226309 hasConceptScore W830226309C95444343 @default.
- W830226309 hasConceptScore W830226309C97029542 @default.
- W830226309 hasLocation W8302263091 @default.
- W830226309 hasLocation W8302263092 @default.
- W830226309 hasOpenAccess W830226309 @default.
- W830226309 hasPrimaryLocation W8302263091 @default.
- W830226309 hasRelatedWork W1976734851 @default.
- W830226309 hasRelatedWork W1986526737 @default.
- W830226309 hasRelatedWork W2004726042 @default.
- W830226309 hasRelatedWork W2025794474 @default.
- W830226309 hasRelatedWork W2095479222 @default.
- W830226309 hasRelatedWork W2185069137 @default.
- W830226309 hasRelatedWork W2369199515 @default.
- W830226309 hasRelatedWork W2579855430 @default.
- W830226309 hasRelatedWork W4254421120 @default.
- W830226309 hasRelatedWork W4361817057 @default.
- W830226309 hasVolume "6" @default.
- W830226309 isParatext "false" @default.
- W830226309 isRetracted "false" @default.
- W830226309 magId "830226309" @default.
- W830226309 workType "article" @default.