FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W83024490> ?p ?o ?g. }

• W83024490 abstract "Controlled release formulations improve drug safety and address patient adherence, barriers that are responsible for 10% of hospitalizations and over $100 billion in annual medical expenses. These benefits apply to medications that require consistent dosing over days, weeks, or months, a category accounting for over 90% of prescription drugs sales. Yet, the use of controlled release formulations remains comparatively sparse because their design requires months of costly experimentation. Significant scholarship has been devoted to facilitating formulation development and to understanding controlled release behavior, particularly in the realm of mathematical modeling. However, each modeling study to date has only focused on predicting the performance of an extremely limited number of “drug”-polymer combinations, vehicle geometries and excipient types. Researchers have yet to arrive at one general theory of controlled release applicable to a wide range of drug delivery systems and have even begun to doubt that one will be developed. To define the underlying mechanisms of controlled release, we studied data from formulations encapsulating a wide variety of agents. Analysis began with poly(lactic-co-glycolic) (PLGA) acid microparticles, yielding a set of equations that predicted the release behavior of neutral or anionic, water-soluble agents from small molecule drugs (~300Da) to viruses. Building from this foundation, new layers of diffusion/reaction equations were added to enable predictions for implant systems and sparingly soluble drugs. These predictions compared favorably to in vitro data from implants that underwent either dissolution-limited or degradation-controlled release. The new predictive models of controlled release enable analytical interpretation of in vitro release data. Their predictions have identified rates and durations of drug release in over 20 systems to date. Calculations of in vitro release also aid in targeting precise release behaviors ranging abrupt bursts to sustained, constant release. These behaviors were realized in a delayed release vaccine, capable of masking antigen from the body until a specific point in time, and as a sustained release formulation that delivered the HIV entry inhibitor, enfuvirtide, for one month. The in vitro and in vivo data from these two proof-of-concept applications support the use of predictive modeling in the design of long-acting controlled release formulations." @default.
• W83024490 created "2016-06-24" @default.
• W83024490 creator A5017343994 @default.
• W83024490 date "2012-01-01" @default.
• W83024490 modified "2023-09-27" @default.
• W83024490 title "APPLICATION OF ENGINEERING PRINCIPLES TO THE DESIGN OF BIODEGRADABLE POLYMER MATRICES FOR CONTROLLED RELEASE" @default.
• W83024490 cites W1515519044 @default.
• W83024490 cites W1539246738 @default.
• W83024490 cites W1543215499 @default.
• W83024490 cites W1582227496 @default.
• W83024490 cites W1597771956 @default.
• W83024490 cites W1964082418 @default.
• W83024490 cites W1964153187 @default.
• W83024490 cites W1965833087 @default.
• W83024490 cites W1971187651 @default.
• W83024490 cites W1972058448 @default.
• W83024490 cites W1972573571 @default.
• W83024490 cites W1972852190 @default.
• W83024490 cites W1973036292 @default.
• W83024490 cites W1973509266 @default.
• W83024490 cites W1975805379 @default.
• W83024490 cites W1975880946 @default.
• W83024490 cites W1976677427 @default.
• W83024490 cites W1977080361 @default.
• W83024490 cites W1977081616 @default.
• W83024490 cites W1978387141 @default.
• W83024490 cites W1979512544 @default.
• W83024490 cites W1979538009 @default.
• W83024490 cites W1980085646 @default.
• W83024490 cites W1980291044 @default.
• W83024490 cites W1981914072 @default.
• W83024490 cites W1981932893 @default.
• W83024490 cites W1982201600 @default.
• W83024490 cites W1983410788 @default.
• W83024490 cites W1983733694 @default.
• W83024490 cites W1984054252 @default.
• W83024490 cites W1985537489 @default.
• W83024490 cites W1985786449 @default.
• W83024490 cites W1986159473 @default.
• W83024490 cites W1986269446 @default.
• W83024490 cites W1986369185 @default.
• W83024490 cites W1986826942 @default.
• W83024490 cites W1987526646 @default.
• W83024490 cites W1988287386 @default.
• W83024490 cites W1988849217 @default.
• W83024490 cites W1989463069 @default.
• W83024490 cites W1990121685 @default.
• W83024490 cites W1990419650 @default.
• W83024490 cites W1990949208 @default.
• W83024490 cites W1991976751 @default.
• W83024490 cites W1992155535 @default.
• W83024490 cites W1992801092 @default.
• W83024490 cites W1993666998 @default.
• W83024490 cites W1994935582 @default.
• W83024490 cites W1995424714 @default.
• W83024490 cites W1996691875 @default.
• W83024490 cites W1997294818 @default.
• W83024490 cites W1998015543 @default.
• W83024490 cites W1999471544 @default.
• W83024490 cites W2001018507 @default.
• W83024490 cites W2001335238 @default.
• W83024490 cites W2001761296 @default.
• W83024490 cites W2001872244 @default.
• W83024490 cites W2001908731 @default.
• W83024490 cites W2002686182 @default.
• W83024490 cites W2005288279 @default.
• W83024490 cites W2008731667 @default.
• W83024490 cites W2010063484 @default.
• W83024490 cites W2010384527 @default.
• W83024490 cites W2011820326 @default.
• W83024490 cites W2012845281 @default.
• W83024490 cites W2013012099 @default.
• W83024490 cites W2014546288 @default.
• W83024490 cites W2015497529 @default.
• W83024490 cites W2015650335 @default.
• W83024490 cites W2015881252 @default.
• W83024490 cites W2016251495 @default.
• W83024490 cites W2016315466 @default.
• W83024490 cites W2016862161 @default.
• W83024490 cites W2016926082 @default.
• W83024490 cites W2017985848 @default.
• W83024490 cites W2018482496 @default.
• W83024490 cites W2019491194 @default.
• W83024490 cites W2020782376 @default.
• W83024490 cites W2021455330 @default.
• W83024490 cites W2022981155 @default.
• W83024490 cites W2024112723 @default.
• W83024490 cites W2024226059 @default.
• W83024490 cites W2024311391 @default.
• W83024490 cites W2027410903 @default.
• W83024490 cites W2027461959 @default.
• W83024490 cites W2030226964 @default.
• W83024490 cites W2030419345 @default.
• W83024490 cites W2031175491 @default.
• W83024490 cites W2031801552 @default.
• W83024490 cites W2032090704 @default.
• W83024490 cites W2032658109 @default.
• W83024490 cites W2035953055 @default.
• W83024490 cites W2037052203 @default.
• W83024490 cites W2037443742 @default.

• next