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• W8302687 abstract "Inhibition of dipeptidyl peptidase IV (DPP-4) is an established approach for the treatment of type 2 diabetes. In 2006, Sitagliptin phosphate, a potent, orally bioavailable and highly selective small molecule DPP-4 inhibitor was approved by the FDA as once daily novel drug for the treatment of type 2 diabetes. Given the clinical success of sitagliptin our laboratories have been interested in generating analogues amenable for once-weekly dosing, to increase medication adherence. The first of such compounds was approved for preclinical and clinical development in 2008. During the back-up development stages, structural chemistry was used to generate new ideas, as well as evaluate in-silico proposals and screening results, and used to guide and significantly accelerate the drug discovery process." @default.
• W8302687 created "2016-06-24" @default.
• W8302687 creator A5055675220 @default.
• W8302687 date "2015-01-01" @default.
• W8302687 modified "2023-10-01" @default.
• W8302687 title "Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors" @default.
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• W8302687 doi "https://doi.org/10.1007/978-94-017-9719-1_5" @default.
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