Matches in SemOpenAlex for { <https://semopenalex.org/work/W830432020> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W830432020 abstract "The retinal pigment epithelial (RPE) cells of several species, including: chicken, rat, mouse and newt, have been observed to undergo a phenomenon known as transdifferentiation. This involves the re-specification of the RPE phenotype towards a neuroretinal, or lens phenotype, in response to various cues, including basic fibroblast growth factor (bFGF). Transdifferentiation has yet to be described in human RPE cells, however, this investigation has demonstrated that human cells, including primary fetal, and human embryonic stem cell-derived (HESC), RPE, may retain the capacity to undergo some level of bFGF-mediated transdifferentiation. It appears that the process is likely comparable to that observed in the embryonic chick model of the phenomenon, given that human transdifferentiation appears to be restricted to the earliest stages of RPE development (approximately 6 weeks). Additionally, the features of transdifferentiated RPE observed in the earliest available human tissue are shown to resemble that of a similar stage in chick development (HH27), which is shown to display limited transdifferentiation for the first time, in contrast with previous studies which report the loss of potential for transdifferentiation at this stage. It remains unclear as to why RPE cells lose the capacity for transdifferentiation with development, however, it appears to be linked to, but not exclusively a result of, a loss in the expression of Pax6 across the RPE monolayer, given both capacity for transdifferentiation, and Pax6 expression, are both variable in different regions of the same monolayer, in the chick model of transdifferentiation. Known RPE augmentation signaling pathways, including bone morphogenic protein (BMP) and Sonic hedgehog (Shh) were analysed for their potential involvement in the restriction of transdifferentiation, however, neither appeared to be directly involved. Further studies in the embryonic chick model of the phenomenon will be necessary to unlock this potential in human RPE cells." @default.
- W830432020 created "2016-06-24" @default.
- W830432020 creator A5051144934 @default.
- W830432020 date "2014-01-28" @default.
- W830432020 modified "2023-09-26" @default.
- W830432020 title "A comparative study of the potential for human retinal pigment epithelium utilising an embryonic chick model of the phenomenon" @default.
- W830432020 hasPublicationYear "2014" @default.
- W830432020 type Work @default.
- W830432020 sameAs 830432020 @default.
- W830432020 citedByCount "0" @default.
- W830432020 crossrefType "dissertation" @default.
- W830432020 hasAuthorship W830432020A5051144934 @default.
- W830432020 hasConcept C104317684 @default.
- W830432020 hasConcept C145103041 @default.
- W830432020 hasConcept C169760540 @default.
- W830432020 hasConcept C2777093970 @default.
- W830432020 hasConcept C2778024200 @default.
- W830432020 hasConcept C2780827179 @default.
- W830432020 hasConcept C28328180 @default.
- W830432020 hasConcept C51816534 @default.
- W830432020 hasConcept C54355233 @default.
- W830432020 hasConcept C55493867 @default.
- W830432020 hasConcept C60870556 @default.
- W830432020 hasConcept C86339819 @default.
- W830432020 hasConcept C86803240 @default.
- W830432020 hasConcept C95444343 @default.
- W830432020 hasConceptScore W830432020C104317684 @default.
- W830432020 hasConceptScore W830432020C145103041 @default.
- W830432020 hasConceptScore W830432020C169760540 @default.
- W830432020 hasConceptScore W830432020C2777093970 @default.
- W830432020 hasConceptScore W830432020C2778024200 @default.
- W830432020 hasConceptScore W830432020C2780827179 @default.
- W830432020 hasConceptScore W830432020C28328180 @default.
- W830432020 hasConceptScore W830432020C51816534 @default.
- W830432020 hasConceptScore W830432020C54355233 @default.
- W830432020 hasConceptScore W830432020C55493867 @default.
- W830432020 hasConceptScore W830432020C60870556 @default.
- W830432020 hasConceptScore W830432020C86339819 @default.
- W830432020 hasConceptScore W830432020C86803240 @default.
- W830432020 hasConceptScore W830432020C95444343 @default.
- W830432020 hasLocation W8304320201 @default.
- W830432020 hasOpenAccess W830432020 @default.
- W830432020 hasPrimaryLocation W8304320201 @default.
- W830432020 hasRelatedWork W1588126314 @default.
- W830432020 hasRelatedWork W1596264327 @default.
- W830432020 hasRelatedWork W1599436863 @default.
- W830432020 hasRelatedWork W2034423403 @default.
- W830432020 hasRelatedWork W2040807722 @default.
- W830432020 hasRelatedWork W2059161758 @default.
- W830432020 hasRelatedWork W2061054953 @default.
- W830432020 hasRelatedWork W2068736745 @default.
- W830432020 hasRelatedWork W2069194529 @default.
- W830432020 hasRelatedWork W2074676039 @default.
- W830432020 hasRelatedWork W2092167465 @default.
- W830432020 hasRelatedWork W2127251089 @default.
- W830432020 hasRelatedWork W2153423562 @default.
- W830432020 hasRelatedWork W2406668630 @default.
- W830432020 hasRelatedWork W2617834470 @default.
- W830432020 hasRelatedWork W2884686477 @default.
- W830432020 hasRelatedWork W301503917 @default.
- W830432020 hasRelatedWork W3037858919 @default.
- W830432020 hasRelatedWork W3080236273 @default.
- W830432020 hasRelatedWork W2105116138 @default.
- W830432020 isParatext "false" @default.
- W830432020 isRetracted "false" @default.
- W830432020 magId "830432020" @default.
- W830432020 workType "dissertation" @default.