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W830443767 abstract "ABSTRACT Objectives : The purpose of this study was to investigate the anti-inflammatory effects of extract from Trogopterorum Faeces (TF) on the RAW 264.7 cells.Methods : To prove the TF's anti-inflammatory effects, we investigated nitric oxide (NO) production and own cell viability. We examined the cytokine pro ductions on lipopolysacchride (LPS)-induced RAW 264.7 cells and also cellular regulatory mec hanisms. Results : TF does not have any cytotoxic effect. TF reduced LPS-induced NO production, interleukin (IL)-1b, IL-6, IL-10 and tumor necrosis factor-a (TNF-a) in RAW 264.7 cells. TF inhibited the activation of mitogen-activated protein kinases ( MAPKs) such as p38, extracelluar signal-regulated kinase (ERK 1/2) and c-Jun NH2-terminal kinase (JNK) and also the degradation of inhibitory kappa B a (Ik-Ba) in the LPS-stimulated RAW 264.7 cells. TF reduced the serum levels of IL-1b, IL-6, TNF-a. The survival rate of LPS-induced endotoxin shock was increased by TF administration.Conclusions : TF down-regulated LPS-induced NO and cytokines production, whic h could provide a clinical basis for anti-inflammatory properties. Key words : Trogopterorum Faeces (TF), lipopolysaccharide (LPS), inflammation. RAW 264.7 cells. Endotoxin shock" @default.
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W830443767 date "2009-01-01" @default.
W830443767 modified "2023-09-26" @default.
W830443767 title "Inhibitory Effect of Extract of Trogopterorum Faeces on the Production of Inflammatory Mediaters" @default.
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