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- W8305364 abstract "Two regional specific inducing factors can be isolated from chick embryos. The “mesodermal” factor is protein in nature and stimulates the competent ectoderm of amphibian gastrulae to form muscle, notochord and pronephros. The “neural” factor induces archencephalic structures. Complex hind-head and tail inductions are very probably formed by a co-operation of the two factors. Both factors are inactivated by trypsin and pepsin. The mesodermal factor is more easily inactivated by heating or incubation with thioglycolic acid. The factors are only starting reaction chains. Further differentiation largely depends on the activation of genes in the reacting tissue. In this respect experiments concerning activation of nuclear RNA synthesis during gastrulation and neurulation and inhibition of differentiation by structural analogs of pyrimidines and pyrimidine nucleosides are discussed." @default.
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- W8305364 date "1963-01-01" @default.
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- W8305364 title "THE ROLE OF REGIONAL SPECIFIC INDUCERS IN THE PRIMARY DETERMINATION AND DIFFERENTIATION OF AMPHIBIA" @default.
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