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- W830582330 abstract "Object:To observe the effect of antisense oligodeoxynucleotides (ASODN) of vascular endothelial growth factor (VEGF) on apoptosis of human leukemic cell line K562 cells. Methods:The cells were divided into VEGF ASODN group,VEGF missense ODN (MSODN) group,and empty control group. K562 cells were treated with phosphorothioate-modified antisense VEGF ODN formulated in cationic polymer in vitro for 48 h. The cell morphology was observed. DNA ladder was detected by gel electrophoresis. Apoptosis was detected by flow cytometric analysis (Annexin Ⅴ-FITC/PI assay). Results:In the ASODN group,the number of cell clusters was decreased and typical apoptosis morphological changes appeared,such as shrinkage of cell bodies,more granular structure in cytoplasm,pyknosis,and DNA fragmentation. In VEGF MSODN group and non transfection group,cells were clustering in suspensions with distinct boundaries and transparent bodies and proliferated prominantly. The DNA ladder was observed in the VEGF ASODN group. But there was only one strand of DNA in the MSODN group and the control group. The apoptotic rate in the ASODN group was 23.28%,which was significantly higher than that in the MSODN group and the control group (P0.05). Conclusion:VEGF ASODN could induce apoptosis of leukemia cells. VEGF was related with anti-apoptosis effect on leukemia cells" @default.
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- W830582330 date "2009-01-01" @default.
- W830582330 modified "2023-09-27" @default.
- W830582330 title "The effect of VEGF antisense oligodeoxynucleotides on apoptosis of leukemia cells." @default.
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