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- W83060011 abstract "The remodelling of connective tissue matrices is fundamentally important for normal growth and development, as well as for the repair and maintenance of the functional integrity of tissues. These remodelling processes are tightly controlled to maintain a fine balance between the extracellular matrix-degrading enzymes and their inhibitors and thus regulate tissue function and development. Matrix degradation is mediated by a variety of proteases, but one family of enzymes in particular, the matrix metalloproteinases (MMPs), have connective tissue macromolecules as their primary targets. Wherever and whenever there is a need for connective tissues to be remodelled, a failure to control the process appropriately will present the possibility of its contribution to the advancement of disease. A number of MMPs have been implicated in the pathogenesis of various chronic diseases such as atherosclerosis, aneurysms, arthritis and cancer. These are complex traits where the disease is influenced by a combination of common variation in a constellation of genes and the effect of a wide range of environmental variables. Thus, the mechanisms underlying the development of the disease will be modulated by genetic diversity and the effect this has on an individual’s response to environmental challenges such as smoking, diet and exercise. This review focuses on the evidence supporting a role for MMPs in the development and progression of cardiovascular disease, for the potential for MMP gene polymorphisms to modulate disease and the impact they may have on therapy." @default.
- W83060011 created "2016-06-24" @default.
- W83060011 creator A5010346589 @default.
- W83060011 date "2004-01-01" @default.
- W83060011 modified "2023-09-27" @default.
- W83060011 title "Genetic Regulation of Metalloproteinase Activity: Pathogenic and Therapeutic Implications" @default.
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- W83060011 doi "https://doi.org/10.1007/978-3-662-06214-2_14" @default.
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