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- W830677543 abstract "Quantitative activation thresholds and cellular membrane reorganization are mechanisms by which resting T cells modulate their response to activating stimuli. Here we demonstrate perturbations of these cellular processes in a unique culture system that non-invasively inhibits T lymphocyte activation. During clinorotation, the T cell activation threshold is increased 5-fold. This increased threshold involves a mechanism independent of TCR triggering. Recruitment of lipid rafts to the activation site is impaired during clinorotation but does occur with increased stimulation. This study describes a situation in which an individual cell senses a change in its physical environment and alters its cell biological behavior." @default.
- W830677543 created "2016-06-24" @default.
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- W830677543 date "2000-01-01" @default.
- W830677543 modified "2023-09-27" @default.
- W830677543 title "T Lymphocyte Activation Threshold and Membrane Reorganization Perturbations in Unique Culture Model" @default.
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