Matches in SemOpenAlex for { <https://semopenalex.org/work/W830881480> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W830881480 abstract "The supply of (–)-hopeaphenol was achieved via enzymatic biotransformation in order to provide material for pre-clinical investigation. High-throughput screening of a pre-fractionated natural product library aimed to identify compounds that inhibit the bacterial virulence type III secretion system (T3SS) identified several fractions derived from two Papua New Guinean Anisoptera species, showing activity against Yersinia pseudotuberculosis outer proteins E and H (YopE and YopH). Bioassay-directed isolation from the leaves of A. thurifera, and similarly A. polyandra, resulted in three known resveratrol tetramers, (–)-hopeaphenol (1), vatalbinoside A (2) and vaticanol B (3). Compounds 1–3 displayed IC50 values of 8.8, 12.5 and 9.9 M in the reporter-gene assay, and IC50 values of 2.9, 4.5 and 3.3 M in the YopH assay, respectively, which suggested that they could potentially act against the T3SS in Yersinia. The structures of 1-3 were confirmed through a combination of spectrometric, chemical methods and single crystal X-ray structure determinations of the natural product 1 and the permethyl ether analogue of 3. The enzymatic hydrolysis of the β-glycoside 2 to the aglycone 1 was achieved through biotransformation using the endogenous leaf enzymes, this significantly enhanced the yield of the desired bioactive natural product from 0.08% to 1.3% and facilitates ADMET studies of (–)-hopeaphenol (1)." @default.
- W830881480 created "2016-06-24" @default.
- W830881480 creator A5013885202 @default.
- W830881480 creator A5018246426 @default.
- W830881480 creator A5019102977 @default.
- W830881480 creator A5035964515 @default.
- W830881480 creator A5042709613 @default.
- W830881480 creator A5044486168 @default.
- W830881480 creator A5046595592 @default.
- W830881480 creator A5054974793 @default.
- W830881480 creator A5061210130 @default.
- W830881480 creator A5062117757 @default.
- W830881480 creator A5066948842 @default.
- W830881480 creator A5084031276 @default.
- W830881480 creator A5084589713 @default.
- W830881480 date "2014-11-01" @default.
- W830881480 modified "2023-10-13" @default.
- W830881480 title "Solving the supply of Resveratrol Tetramers from Papua New Guinean rainforest Anisoptera species (Dipterocarpaceae) that inhibit bacterial type III secretion systems" @default.
- W830881480 cites W154743337 @default.
- W830881480 cites W1601269391 @default.
- W830881480 hasPublicationYear "2014" @default.
- W830881480 type Work @default.
- W830881480 sameAs 830881480 @default.
- W830881480 citedByCount "0" @default.
- W830881480 crossrefType "journal-article" @default.
- W830881480 hasAuthorship W830881480A5013885202 @default.
- W830881480 hasAuthorship W830881480A5018246426 @default.
- W830881480 hasAuthorship W830881480A5019102977 @default.
- W830881480 hasAuthorship W830881480A5035964515 @default.
- W830881480 hasAuthorship W830881480A5042709613 @default.
- W830881480 hasAuthorship W830881480A5044486168 @default.
- W830881480 hasAuthorship W830881480A5046595592 @default.
- W830881480 hasAuthorship W830881480A5054974793 @default.
- W830881480 hasAuthorship W830881480A5061210130 @default.
- W830881480 hasAuthorship W830881480A5062117757 @default.
- W830881480 hasAuthorship W830881480A5066948842 @default.
- W830881480 hasAuthorship W830881480A5084031276 @default.
- W830881480 hasAuthorship W830881480A5084589713 @default.
- W830881480 hasConcept C181199279 @default.
- W830881480 hasConcept C185592680 @default.
- W830881480 hasConcept C194671627 @default.
- W830881480 hasConcept C2776816829 @default.
- W830881480 hasConcept C2778382314 @default.
- W830881480 hasConcept C2779396153 @default.
- W830881480 hasConcept C2779396346 @default.
- W830881480 hasConcept C27881333 @default.
- W830881480 hasConcept C55493867 @default.
- W830881480 hasConcept C71240020 @default.
- W830881480 hasConcept C86803240 @default.
- W830881480 hasConceptScore W830881480C181199279 @default.
- W830881480 hasConceptScore W830881480C185592680 @default.
- W830881480 hasConceptScore W830881480C194671627 @default.
- W830881480 hasConceptScore W830881480C2776816829 @default.
- W830881480 hasConceptScore W830881480C2778382314 @default.
- W830881480 hasConceptScore W830881480C2779396153 @default.
- W830881480 hasConceptScore W830881480C2779396346 @default.
- W830881480 hasConceptScore W830881480C27881333 @default.
- W830881480 hasConceptScore W830881480C55493867 @default.
- W830881480 hasConceptScore W830881480C71240020 @default.
- W830881480 hasConceptScore W830881480C86803240 @default.
- W830881480 hasLocation W8308814801 @default.
- W830881480 hasOpenAccess W830881480 @default.
- W830881480 hasPrimaryLocation W8308814801 @default.
- W830881480 hasRelatedWork W2081511876 @default.
- W830881480 hasRelatedWork W2477876699 @default.
- W830881480 hasRelatedWork W2735663364 @default.
- W830881480 hasRelatedWork W2883017783 @default.
- W830881480 hasRelatedWork W2887388421 @default.
- W830881480 hasRelatedWork W2950497317 @default.
- W830881480 hasRelatedWork W3082590213 @default.
- W830881480 hasRelatedWork W2992751016 @default.
- W830881480 isParatext "false" @default.
- W830881480 isRetracted "false" @default.
- W830881480 magId "830881480" @default.
- W830881480 workType "article" @default.