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• W830963876 abstract "Blood flow is controlled by an integrated network of resistance arteries that are coupled in series and parallel with one another. To dramatically alter tissue perfusion as required during periods of high metabolic demand, arterial networks must dilate in a coordinated manner. Gap junctions facilitate arterial coordination by enabling electrical stimuli to conduct among endothelial and (or) smooth muscle cells. The goal of this review was to provide an introduction to the field of vascular communication, the process of intercellular conduction, and the manner in which key properties influence charge flow. After a brief historical introduction, we establish the idea that electrical stimuli conduct differentially among neighbouring endothelial and smooth muscle cells. Highlighting recent studies that have synergistically combined computational and experimental approaches, this perspective explores how specific structural, electrical, and gap junctional properties enable electrical phenomenon to conduct differentially. To close, the concept of differential communication is functionally integrated into a mechanistic understanding of blood flow control." @default.
• W830963876 created "2016-06-24" @default.
• W830963876 creator A5068389319 @default.
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• W830963876 date "2009-01-01" @default.
• W830963876 modified "2023-10-15" @default.
• W830963876 title "Current perspective on differential communication in small resistance arteriesThis article is part of a Special Issue on Information Transfer in the Microcirculation." @default.
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• W830963876 doi "https://doi.org/10.1139/y08-104" @default.
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