Matches in SemOpenAlex for { <https://semopenalex.org/work/W83098975> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W83098975 abstract "Abstract : We propose to conjugate paclitaxel to a single-chain antibody that specifically binds to the extracellular domain of the EGFR. The scFv-paclitaxel conjugate will be able to localize to the tumor rapidly, penetrate deeper, be eliminated quickly, and induce fewer side effects for the patient, thereby increasing the efficacy of the scFv-paclitaxel conjugate. An additional benefit with the scFv-paclitaxel conjugate is the fact that taxol is a radiosensitizing drug, therefore radiation treatment can be used following the administration of the scFv-paclitaxel conjugate. The EGFR overexpressing breast cancer cell line, MDA-MB-468 will be used in this proposal to show 'proof of concept'. Cell proliferation assays will be used to examine the cytotoxicity of the scFv-paclitaxel conjugate as compared to paclitaxel, scFv or the combination of the two agents. Cell death will be examined using two different apoptosis assays, annexin V-FITC and TUNEL. Since taxol is a radio sensitizing drug, radiation will be included in the cell proliferation and apoptosis assays. Clonogenic assays will be done to determine the radio sensitizing ability of the scFv-paclitaxel conjugate as compare to each agent alone." @default.
- W83098975 created "2016-06-24" @default.
- W83098975 creator A5078082133 @default.
- W83098975 date "2001-09-01" @default.
- W83098975 modified "2023-09-28" @default.
- W83098975 title "EGFR-Specific Single-Chain Antibody-Taxol Conjugate for Radiosensitizing Breast Carcinomas" @default.
- W83098975 cites W1484092314 @default.
- W83098975 cites W1536306303 @default.
- W83098975 cites W2013878898 @default.
- W83098975 cites W2053675669 @default.
- W83098975 cites W2071803379 @default.
- W83098975 cites W2087770415 @default.
- W83098975 cites W96339728 @default.
- W83098975 doi "https://doi.org/10.21236/ada398936" @default.
- W83098975 hasPublicationYear "2001" @default.
- W83098975 type Work @default.
- W83098975 sameAs 83098975 @default.
- W83098975 citedByCount "0" @default.
- W83098975 crossrefType "report" @default.
- W83098975 hasAuthorship W83098975A5078082133 @default.
- W83098975 hasConcept C109316439 @default.
- W83098975 hasConcept C121608353 @default.
- W83098975 hasConcept C126322002 @default.
- W83098975 hasConcept C134306372 @default.
- W83098975 hasConcept C159654299 @default.
- W83098975 hasConcept C185592680 @default.
- W83098975 hasConcept C190283241 @default.
- W83098975 hasConcept C197336794 @default.
- W83098975 hasConcept C202751555 @default.
- W83098975 hasConcept C203014093 @default.
- W83098975 hasConcept C2777292972 @default.
- W83098975 hasConcept C2777325958 @default.
- W83098975 hasConcept C33923547 @default.
- W83098975 hasConcept C502942594 @default.
- W83098975 hasConcept C542903549 @default.
- W83098975 hasConcept C55493867 @default.
- W83098975 hasConcept C71924100 @default.
- W83098975 hasConcept C98274493 @default.
- W83098975 hasConceptScore W83098975C109316439 @default.
- W83098975 hasConceptScore W83098975C121608353 @default.
- W83098975 hasConceptScore W83098975C126322002 @default.
- W83098975 hasConceptScore W83098975C134306372 @default.
- W83098975 hasConceptScore W83098975C159654299 @default.
- W83098975 hasConceptScore W83098975C185592680 @default.
- W83098975 hasConceptScore W83098975C190283241 @default.
- W83098975 hasConceptScore W83098975C197336794 @default.
- W83098975 hasConceptScore W83098975C202751555 @default.
- W83098975 hasConceptScore W83098975C203014093 @default.
- W83098975 hasConceptScore W83098975C2777292972 @default.
- W83098975 hasConceptScore W83098975C2777325958 @default.
- W83098975 hasConceptScore W83098975C33923547 @default.
- W83098975 hasConceptScore W83098975C502942594 @default.
- W83098975 hasConceptScore W83098975C542903549 @default.
- W83098975 hasConceptScore W83098975C55493867 @default.
- W83098975 hasConceptScore W83098975C71924100 @default.
- W83098975 hasConceptScore W83098975C98274493 @default.
- W83098975 hasLocation W830989751 @default.
- W83098975 hasOpenAccess W83098975 @default.
- W83098975 hasPrimaryLocation W830989751 @default.
- W83098975 hasRelatedWork W1619044237 @default.
- W83098975 hasRelatedWork W2001054044 @default.
- W83098975 hasRelatedWork W2022750430 @default.
- W83098975 hasRelatedWork W2025535465 @default.
- W83098975 hasRelatedWork W2032912375 @default.
- W83098975 hasRelatedWork W2040777081 @default.
- W83098975 hasRelatedWork W2049126730 @default.
- W83098975 hasRelatedWork W2093844688 @default.
- W83098975 hasRelatedWork W2104150310 @default.
- W83098975 hasRelatedWork W2134603491 @default.
- W83098975 hasRelatedWork W2142325694 @default.
- W83098975 hasRelatedWork W2152095899 @default.
- W83098975 hasRelatedWork W2269649834 @default.
- W83098975 hasRelatedWork W2328427376 @default.
- W83098975 hasRelatedWork W2403500327 @default.
- W83098975 hasRelatedWork W2921304347 @default.
- W83098975 hasRelatedWork W3010772258 @default.
- W83098975 hasRelatedWork W3013947368 @default.
- W83098975 hasRelatedWork W3039998283 @default.
- W83098975 hasRelatedWork W2921660378 @default.
- W83098975 isParatext "false" @default.
- W83098975 isRetracted "false" @default.
- W83098975 magId "83098975" @default.
- W83098975 workType "report" @default.