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• W83145613 abstract "We compared the immunohistochemical expression of PTEN, estrogen receptor α (ER- α) and progesterone receptor (PR) in a series of endometrial hyperplasia (EH) and in disordered proliferative endometrium (DPE) by tissue microarray (TMA). The material consisted of 141 endometrial curretings including 98 cases (study group) diagnosed as EH [59-simple (SH), 20-complex (CH), 19 atypical (AEH)] and 43 cas es (control group) with DPE due to anovulation. The mean PTEN expression index decreased in order DPE-EH-AEH groups (p 0.05 and p > 0.05, re spectively). These results show that steroid hormone receptor status influences the architectural changes of endometrium rather than cytological ones. On the other hand, decreased PTEN expression correlates more closely with the cytological atypia in en dometrial cells. In our opinion ER- α and PR may be useful markers predicting ther apy response in EH. PTEN presents as a strong prognosticator which may help in determining the risk of progression in advanced stages of EH, especially those with atypical cytological features." @default.
• W83145613 created "2016-06-24" @default.
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• W83145613 date "2011-11-17" @default.
• W83145613 modified "2023-09-23" @default.
• W83145613 title "Analysis of PTEN, estrogen receptor α and progesterone receptor expression in endometrial hyperplasia using tissue microarray." @default.
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