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- W83178076 abstract "Abstract Lactobacilli are part of the normal flora of the urogenital tract, and are used to restore the bacterial balance of the gastrointestinal, urogenital and respiratory tracts. We studied whether lactic acid bacteria could be used as probiotics in the urinary tract in order to prevent colonization of uropathogens in the epithelium. The strains used were Lactobacillus fermentum CRL 1058 and the uropathogenic strains Escherichia coli and Klebsiella pneumoniae . Lactobacillus fermentum , attached to agarose beads, was inoculated intra-urethrally into 2-month-old female BALB/c mice in different doses. These mice were then challenged by the same method with E. coli or K. pneumoniae . A reasonable double dose of lactobacilli (10 7 CFU per dose) was adequate to protect the mice since pathogens disappeared completely by the third day after challenge. Using a lower lactobacilli double dose (10 5 CFU per dose), the number of E. coli recovered in the urogenital tract of challenged mice was lower than in control animals, but did not disappear completely. However, lactobacilli failed to exert a protective effect against K. pneumoniae colonization. No increase in the levels of either anti-lactobacilli or anti- K. pneumoniae antibodies was observed up to the 25 th day in mice treated with lactobacilli. A remarkable variation of the level of lactate dehydrogenase and a slight increase of anti- E. coli antibodies were found in animals infected with E. coli , while polymorphonuclear leucocytes were observed in the urine of animals infected with K. pneumoniae . A therapeutic assay against both pathogens could not be achieved; a decrease in the number of E. coli in the organs of animals treated with lacobacilli only was observed. Our results suggest that L. fermentum could be used as a probiotic to prevent and avoid urinary tract infections caused by E. coli but not those caused by capsulated pathogens such as K. pneumoniae ." @default.
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- W83178076 date "1996-04-01" @default.
- W83178076 modified "2023-09-27" @default.
- W83178076 title "Preventive and Therapeutic Effects of Lactobacilli on Urinary Tract Infections in Mice CLINICAL MICROBIOLOGY" @default.
- W83178076 doi "https://doi.org/10.1006/anae.1996.0011" @default.
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