Matches in SemOpenAlex for { <https://semopenalex.org/work/W831991621> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W831991621 endingPage "122" @default.
- W831991621 startingPage "118" @default.
- W831991621 abstract "The objective of the present investigation was to study pharmacokinetics of promethazine in Korean healthy subjects using a validated HPLC method. The HPLC analysis was performed on a Capcell Pak CN column with a mixture of acetonitrile-0.02M potassium dihydrogen phosphate (42:58, v/v, pH 6.0) and the analyte was quantified with UV detection at 251 nm. The calibration curve of the drug was linear over the range of 1-40ng/mL in human serum and the limit of quantification (LOQ) was 1 ng/mL. This analytical method was validated and shown to be specific, accurate, precise and reproducible. This method was applied to pharmacokinetic study of promethazine in Korean healthy volunteers following an oral administration of two 25 mg Himazin tablets (50 mg promethazine HCI) after overnight fasting. Serum samples were collected at given intervals over a 36-hour period (12 points) and pharmacokinetic parameters were determined from serum concentration-time profile using WinNonlin program. The estimated , , , and of promethazine obtained from Korean healthy subjects were 103.84 84.30 nghr/mL, 87.9481.02 nghr/mL, 13.4310.92 ng/mL, 2.001.16 hr and 5.883.47 hr, respectively." @default.
- W831991621 created "2016-06-24" @default.
- W831991621 creator A5020122986 @default.
- W831991621 creator A5038103243 @default.
- W831991621 creator A5041358794 @default.
- W831991621 creator A5073441600 @default.
- W831991621 creator A5075893557 @default.
- W831991621 creator A5085711009 @default.
- W831991621 date "2005-06-01" @default.
- W831991621 modified "2023-09-24" @default.
- W831991621 title "Pharmacokinetic Study of Promethazine in Korean Healthy Subjects Using a Validated HPLC Method" @default.
- W831991621 hasPublicationYear "2005" @default.
- W831991621 type Work @default.
- W831991621 sameAs 831991621 @default.
- W831991621 citedByCount "0" @default.
- W831991621 crossrefType "journal-article" @default.
- W831991621 hasAuthorship W831991621A5020122986 @default.
- W831991621 hasAuthorship W831991621A5038103243 @default.
- W831991621 hasAuthorship W831991621A5041358794 @default.
- W831991621 hasAuthorship W831991621A5073441600 @default.
- W831991621 hasAuthorship W831991621A5075893557 @default.
- W831991621 hasAuthorship W831991621A5085711009 @default.
- W831991621 hasConcept C10390740 @default.
- W831991621 hasConcept C112705442 @default.
- W831991621 hasConcept C119128265 @default.
- W831991621 hasConcept C178790620 @default.
- W831991621 hasConcept C179998833 @default.
- W831991621 hasConcept C185592680 @default.
- W831991621 hasConcept C23531484 @default.
- W831991621 hasConcept C2778794651 @default.
- W831991621 hasConcept C42404028 @default.
- W831991621 hasConcept C43617362 @default.
- W831991621 hasConcept C517785266 @default.
- W831991621 hasConcept C71924100 @default.
- W831991621 hasConcept C98274493 @default.
- W831991621 hasConceptScore W831991621C10390740 @default.
- W831991621 hasConceptScore W831991621C112705442 @default.
- W831991621 hasConceptScore W831991621C119128265 @default.
- W831991621 hasConceptScore W831991621C178790620 @default.
- W831991621 hasConceptScore W831991621C179998833 @default.
- W831991621 hasConceptScore W831991621C185592680 @default.
- W831991621 hasConceptScore W831991621C23531484 @default.
- W831991621 hasConceptScore W831991621C2778794651 @default.
- W831991621 hasConceptScore W831991621C42404028 @default.
- W831991621 hasConceptScore W831991621C43617362 @default.
- W831991621 hasConceptScore W831991621C517785266 @default.
- W831991621 hasConceptScore W831991621C71924100 @default.
- W831991621 hasConceptScore W831991621C98274493 @default.
- W831991621 hasIssue "2" @default.
- W831991621 hasLocation W8319916211 @default.
- W831991621 hasOpenAccess W831991621 @default.
- W831991621 hasPrimaryLocation W8319916211 @default.
- W831991621 hasRelatedWork W1522727282 @default.
- W831991621 hasRelatedWork W1866040265 @default.
- W831991621 hasRelatedWork W2014502581 @default.
- W831991621 hasRelatedWork W2041585586 @default.
- W831991621 hasRelatedWork W2058775055 @default.
- W831991621 hasRelatedWork W2081211217 @default.
- W831991621 hasRelatedWork W2086990283 @default.
- W831991621 hasRelatedWork W2134119846 @default.
- W831991621 hasRelatedWork W2134379934 @default.
- W831991621 hasRelatedWork W2326439508 @default.
- W831991621 hasRelatedWork W2372937868 @default.
- W831991621 hasRelatedWork W2382342235 @default.
- W831991621 hasRelatedWork W2391610358 @default.
- W831991621 hasRelatedWork W2399854933 @default.
- W831991621 hasRelatedWork W2698251735 @default.
- W831991621 hasRelatedWork W813180435 @default.
- W831991621 hasRelatedWork W897696740 @default.
- W831991621 hasRelatedWork W2080078481 @default.
- W831991621 hasRelatedWork W2187535767 @default.
- W831991621 hasRelatedWork W2561759931 @default.
- W831991621 hasVolume "13" @default.
- W831991621 isParatext "false" @default.
- W831991621 isRetracted "false" @default.
- W831991621 magId "831991621" @default.
- W831991621 workType "article" @default.