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- W833460038 abstract "This chapter discusses the classical distinguishing characteristics of persistent pathogens, that they elicit host responses, including inflammation, and that they have the capacity to damage the host, are increasingly being associated with the so-called commensal flora as well. The focus is mainly on the normal flora of the gastrointestinal tract. All external and certain, but not all, internal body surfaces are covered by a film of microorganisms, a normal microflora. The upper respiratory tract, gastrointestinal tract, perineum, vagina, and distal urethra contain large resident bacterial populations, while the bronchi, alveolar spaces, urinary tract, and uterus are normally sterile. Macrophages from animals colonized by a microflora also display increased cytotoxic activity, secrete more oxygen radicals, have increased levels of cyclic AMP, and produce more interleukin 1 (IL-1), IL-6, and tumor necrosis factor alpha in response to lipopolysaccharide (LPS) than macrophages from germfree animals. Intestinal immune responses are mainly induced in the Peyer's patches, which are mucosal lymphoid nodules covered by a specialized epithelium, the follicle-associated epithelium. Oral tolerance also protects us from exaggerated responsiveness, including inflammatory responses to antigens which are not dangerous, and thus minimizes the risk of inflammatory states in the mucosa. Colon cancer is one of the most common neoplastic diseases in wealthy populations but is relatively uncommon in developing countries. Staphylococci have been implicated in the pathogenesis of atopic dermatitis. Evidently, the epidemiological connection between the intestinal colonization pattern and allergy development needs to be further studied." @default.
- W833460038 created "2016-06-24" @default.
- W833460038 creator A5047659498 @default.
- W833460038 creator A5072812522 @default.
- W833460038 date "2014-04-08" @default.
- W833460038 modified "2023-09-27" @default.
- W833460038 title "Pathological Consequences of Commensalism" @default.
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