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- W83408045 endingPage "31" @default.
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- W83408045 abstract "About one third of patients who will receive a cancer diagnostic will die of this disease. In most cases, death results from the formation of secondary neoplasms called metastases. The metastatic process is characterized by the detachment of cancer cells from the primary sites followed by their dissemination throughout the bloodstream and/or lymph stream to distal sites where they proliferate to give rise to secondary tumours. Intriguingly, the metastatic process is rather inefficient and in spite of its clinical significance, it remains poorly understood. Nevertheless, significant progress has been achieved during the past years and the increasing knowledge of the metastatic process is encouraging and raises high therapeutic expectations. Several events that lead to cancer and metastasis are under genetic and epigenetic controls. In particular, cancer initiation is tightly associated with specific mutations that affect proto-oncogenes and tumour suppressor genes. These mutations lead to unrestrained growth of the primary neoplasm and to a propensity to detach and progress through the subsequent steps of metastatic dissemination. Epigenetic alterations are mainly characterized by deregulation of DNA methylation and microRNA (miRNA)-dependent functions, as well as disruption of histone modifiers and chromatin-remodelling factors. In addition to these molecular alterations, several studies highlight that tumour development and dissemination rely on a continuous crosstalk between cancer cells and their microenvironments. This chapter will provide an overview of the metastatic process as it applies to colorectal cancer." @default.
- W83408045 created "2016-06-24" @default.
- W83408045 creator A5012719405 @default.
- W83408045 creator A5063980572 @default.
- W83408045 creator A5072493213 @default.
- W83408045 date "2010-01-01" @default.
- W83408045 modified "2023-10-01" @default.
- W83408045 title "The Metastatic Process: An Overview" @default.
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