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- W834212287 abstract "Study objective. To investigate efficacy and safety of amlodipine (Cardilopine) in the elderly hypertensive patients.Patients and methods. 34 pateints on 65-79 years old with uncomplicated stage 1-3 hypertension were studied. Systolodiastoloc hypertension (SDH) was in 61,76% of cases, isilated systolic hypertension (ISH) in 38,24%. Hypertension duration was 11,18±1,26 yrs. Crdilopine EGIS) was administrated once daily in dose 5 mg. After one month of treatment the dose was increased or hydrochlorothiazide added. 24 blood pressure monitoring was performed at baseline and after 3 and 12 months of treatment. Treatment efficacy was evaluated according to criteria of Kobalava G (2002). Drug safety was analyzed according to side effects registration.Results. The blood pressure was reduced by 39,07/16,27 mm Hg and 21,69/3,60 mm Gh respectively (p<0,001), pulse pressure was also reduced. Blood pressure variability was normalized during 24-hors and mean daytime. The morning surge of blood pressure also decreased. The was a tendency for normalization of diurnal pressure rhythm - the number of night-peakers reduced and proportion of dippers increased. Effect of therapy was observed in 93,33% of patients.Conclusions. Cardilopin is effective and well-tolerated in elderly hypertensive patients." @default.
- W834212287 created "2016-06-24" @default.
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- W834212287 date "2008-02-28" @default.
- W834212287 modified "2023-10-05" @default.
- W834212287 title "Efficacy and safety of calcium antagonists intreatment of hypertension in the alderly: focuson amlodipine" @default.
- W834212287 doi "https://doi.org/10.18705/1607-419x-2008-14-1-59-64" @default.
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