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- W834226327 abstract "Microbial keratitis is a significant cause of global visual impairment and blindness. Corneal infection can be caused by a wide variety of pathogens, each of which exhibits a range of mechanisms by which the immune system is activated. The complexity of the immune response to corneal infection is only now beginning to be elucidated. Crucial to the cornea's defences are the pattern-recognition receptors: Toll-like and Nod-like receptors and the subsequent activation of inflammatory pathways. These inflammatory pathways include the inflammasome and can lead to significant tissue destruction and corneal damage, with the potential for resultant blindness. Understanding the immune mechanisms behind this tissue destruction may enable improved identification of therapeutic targets to aid development of more specific therapies for reducing corneal damage in infectious keratitis. This review summarises current knowledge of pattern-recognition receptors and their downstream pathways in response to the major keratitis-causing organisms and alludes to potential therapeutic approaches that could alleviate corneal blindness." @default.
- W834226327 created "2016-06-24" @default.
- W834226327 creator A5018514304 @default.
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- W834226327 creator A5025970384 @default.
- W834226327 creator A5033439222 @default.
- W834226327 creator A5087853709 @default.
- W834226327 date "2015-07-10" @default.
- W834226327 modified "2023-10-09" @default.
- W834226327 title "Pattern recognition receptors in microbial keratitis" @default.
- W834226327 cites W113642018 @default.
- W834226327 cites W123902827 @default.
- W834226327 cites W141456527 @default.
- W834226327 cites W1483162601 @default.
- W834226327 cites W1501836292 @default.
- W834226327 cites W1512191088 @default.
- W834226327 cites W1515229856 @default.
- W834226327 cites W1529674879 @default.
- W834226327 cites W1537546513 @default.
- W834226327 cites W1549973279 @default.
- W834226327 cites W1555833585 @default.
- W834226327 cites W1562869551 @default.
- W834226327 cites W1584789188 @default.
- W834226327 cites W1585706755 @default.
- W834226327 cites W1615829672 @default.
- W834226327 cites W161667556 @default.
- W834226327 cites W1712936277 @default.
- W834226327 cites W1754166442 @default.
- W834226327 cites W1928475442 @default.
- W834226327 cites W1959357132 @default.
- W834226327 cites W1960164399 @default.
- W834226327 cites W1963064194 @default.
- W834226327 cites W1964538728 @default.
- W834226327 cites W1966136640 @default.
- W834226327 cites W1967831753 @default.
- W834226327 cites W1968931227 @default.
- W834226327 cites W1971915082 @default.
- W834226327 cites W1972543205 @default.
- W834226327 cites W1972548233 @default.
- W834226327 cites W1973202015 @default.
- W834226327 cites W1973682675 @default.
- W834226327 cites W197411503 @default.
- W834226327 cites W1975032025 @default.
- W834226327 cites W1975262958 @default.
- W834226327 cites W1977249590 @default.
- W834226327 cites W1979318608 @default.
- W834226327 cites W1980254567 @default.
- W834226327 cites W1980768668 @default.
- W834226327 cites W1980826113 @default.
- W834226327 cites W1982655562 @default.
- W834226327 cites W1982775201 @default.
- W834226327 cites W1983485704 @default.
- W834226327 cites W1983588581 @default.
- W834226327 cites W1984190306 @default.
- W834226327 cites W1984409867 @default.
- W834226327 cites W1985538633 @default.
- W834226327 cites W1986178107 @default.
- W834226327 cites W1988197452 @default.
- W834226327 cites W1990454272 @default.
- W834226327 cites W1994656524 @default.
- W834226327 cites W1995576415 @default.
- W834226327 cites W1997221411 @default.
- W834226327 cites W2000349011 @default.
- W834226327 cites W2000528550 @default.
- W834226327 cites W2001160691 @default.
- W834226327 cites W2001371234 @default.
- W834226327 cites W2003168401 @default.
- W834226327 cites W2003719743 @default.
- W834226327 cites W2003738186 @default.
- W834226327 cites W2004205866 @default.
- W834226327 cites W2005220504 @default.
- W834226327 cites W2009392385 @default.
- W834226327 cites W2010905723 @default.
- W834226327 cites W2011172868 @default.
- W834226327 cites W2011678998 @default.
- W834226327 cites W2012896617 @default.
- W834226327 cites W2013601771 @default.
- W834226327 cites W2018664981 @default.
- W834226327 cites W2018995582 @default.
- W834226327 cites W2019039210 @default.
- W834226327 cites W2020096288 @default.
- W834226327 cites W2021019212 @default.
- W834226327 cites W2021193191 @default.
- W834226327 cites W2025896394 @default.
- W834226327 cites W2026263963 @default.
- W834226327 cites W2027584979 @default.
- W834226327 cites W2030144214 @default.
- W834226327 cites W2032120870 @default.
- W834226327 cites W2032188844 @default.
- W834226327 cites W2033236322 @default.
- W834226327 cites W2033415145 @default.
- W834226327 cites W2034230597 @default.
- W834226327 cites W2034451487 @default.
- W834226327 cites W2035771552 @default.
- W834226327 cites W2036348588 @default.
- W834226327 cites W2037030215 @default.
- W834226327 cites W2037124635 @default.
- W834226327 cites W2041297702 @default.