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• W834578082 abstract "Biochanin A, an isoflavone isolated from red clover, cabbage or alfalfa, has been reported to have anti-inflammatory activity. However, the effects of biochanin A on vascular inflammation have not been investigated. In this study, we investigate the anti-inflammatory effects of biochanin A on lipopolysaccharide (LPS)-induced inflammatory response in human umbilical vein endothelial cells (HUVEC cells).The HUVEC cells were treated with biochanin A for 12h before exposure to LPS. The expression of ECAMs, including VCAM-1, ICAM-1, E-selectin, NF-κB and PPAR-γ was detected by Western blotting. The expression of cytokines TNF-α and IL-8 was detected by ELISA.The results showed that biochanin A inhibited LPS-induced TNF-α and IL-8 production. Meanwhile, biochanin A also suppressed VCAM-1, ICAM-1, and E-selectin expression induced by LPS. We also found that biochanin A inhibited NF-κB activation induced by LPS. Furthermore, biochanin A could activate PPAR-γ and the anti-inflammatory effects of biochanin A can be reversed by GW9662, a specific antagonist for PPAR-γ.In conclusion, the anti-inflammatory effect of biochanin A is associated with activating PPAR-γ, thereby attenuating NF-κB activation and LPS-induced inflammatory response. These findings suggest that biochanin A may be a therapeutic agent for inflammatory cardiovascular disease." @default.
• W834578082 created "2016-06-24" @default.
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• W834578082 date "2015-09-01" @default.
• W834578082 modified "2023-10-03" @default.
• W834578082 title "Biochanin A inhibits lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells" @default.
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• W834578082 doi "https://doi.org/10.1016/j.lfs.2015.06.015" @default.
• W834578082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26141992" @default.
• W834578082 hasPublicationYear "2015" @default.
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