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- W83504702 abstract "The receptor activity-modifying protein (RAMP) family of membrane proteins regulates G protein-coupled receptor (GPCR) function in several ways. RAMPs can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, several small molecule antagonists of RAMP1/ calcitonin receptor-like receptor complexes, which block the actions of the neuropeptide calcitonin gene-related peptide are in development for the treatment of migraine headache." @default.
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- W83504702 date "2012-01-01" @default.
- W83504702 modified "2023-10-18" @default.
- W83504702 title "RAMPs as Drug Targets" @default.
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- W83504702 doi "https://doi.org/10.1007/978-1-4614-2364-5_6" @default.
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