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- W83510084 abstract "Infection or vaccination with an influenza virus induces a variety of humoral and cellular immune responses. Among these, the subtype specificity and duration of antibody responses most closely match related characteristics of infection-induced immunity in man. Furthermore, in vitro and in vivo animal studies suggest that the most probable mediator of resistance to influenza is antibody to the hemagglutinin (HA), either in serum or respiratory secretions. A role for anti-HA antibody in secretions was sought in human studies utilizing immunization followed by virus challenge and sensitive radio-immunoprecipitation assays for detection of antibody. Serum IgG antibody was more consistently and more strongly related to resistance to challenge than was antibody in secretions. Moreover, passive immunization of infants has been recently shown to be associated with immunity to influenza. Thus, we believe currently available evidence favors the concept that serum IgG antibody to the influenza virus hemagglutinin is not only the best correlate but is probably the primary mediator of immunity to influenza." @default.
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- W83510084 date "1981-01-01" @default.
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- W83510084 title "THE BASIS FOR IMMUNITY TO INFLUENZA IN MAN" @default.
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- W83510084 doi "https://doi.org/10.1016/b978-0-12-515080-4.50046-8" @default.
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