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- W835304800 abstract "In the present study, to find molecular mechanism of UVB induced matrix metalloproteinase (MMPs) in skin fibroblasts, we investigated the effect of fucoidan on the MMP-1 mRNA level and promoter activity. Fucoidan treatment of 0, 1, 10, 100 μg/mL concentration. The cells were incubated for 24 hr and after UVB irradiation, they were then further harvested. mRNA expression of MMPs was estimated by using RT-PCR. The cells pretreated with fucoidan were inhibited in the expression of MMP-1 at mRNA levels in the following order; 100 μg/mL> 10 μg/mL > 1 μg/mL compared to the control. In order to study the inhibitory effects of fucoidan on UVB-induced MMP-1 expression at transcription level, luciferase assay was performed using pGL3 MMP-1 construct. To examine the roles of UVB in MMP-1 promoter activity, a luciferase assay was performed at 0, 6hr, 12hr and 24hr after UVB (100 mJ/cm2) exposure. MMP-1 promoter activity was maximally induced at 6hr after UVB irradiation and subsequently declined to basal levels in cells. In conclusion, fucoidan may down-regulated MMP-1 promoter and induce inhibition of MMP-1 mRNA. Through this mechanism, fucoidan may have anti-photoaging effect. *This work was supported by the grant of KICOS" @default.
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- W835304800 date "2008-03-01" @default.
- W835304800 modified "2023-10-14" @default.
- W835304800 title "Effect of fucoidan on mRNA and promoter activity of matrix metalloproteinases(MMPs) in skin fibroblasts" @default.
- W835304800 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1014.2" @default.
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