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• W8353607 abstract "Research Article1 December 1992free access Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice. J.A. Sharpe J.A. Sharpe MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author P.S. Chan-Thomas P.S. Chan-Thomas MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author J. Lida J. Lida MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author H. Ayyub H. Ayyub MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author W.G. Wood W.G. Wood MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author D.R. Higgs D.R. Higgs MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author J.A. Sharpe J.A. Sharpe MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author P.S. Chan-Thomas P.S. Chan-Thomas MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author J. Lida J. Lida MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author H. Ayyub H. Ayyub MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author W.G. Wood W.G. Wood MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author D.R. Higgs D.R. Higgs MRC Molecular Haematology Unit, University of Oxford, UK. Search for more papers by this author Author Information J.A. Sharpe1, P.S. Chan-Thomas1, J. Lida1, H. Ayyub1, W.G. Wood1 and D.R. Higgs1 1MRC Molecular Haematology Unit, University of Oxford, UK. The EMBO Journal (1992)11:4565-4572https://doi.org/10.1002/j.1460-2075.1992.tb05558.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have analysed the effect of a 1.4 kb segment of DNA containing the upstream alpha globin regulatory element (HS-40) on human alpha globin gene expression in fetal mice and lines of transgenic mice. High levels of tissue-specific, human alpha mRNA expression were seen in all transgenic animals and in this sense expression was position independent. However, the level of human alpha mRNA expression per integrated gene copy decreased during development and was inversely related to copy number. The limitation in expression with increasing gene copy number was shown to be in cis since homozygotes for the transgene produced twice as much human alpha mRNA as hemizygotes. In many respects HS −40 appears similar to single elements within the previously described beta globin locus control region and in cross breeding experiments we have shown that HS −40 behaves in a similar manner to such elements in transgenic mice. Previous ArticleNext Article Volume 11Issue 121 December 1992In this issue RelatedDetailsLoading ..." @default.
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• W8353607 title "Analysis of the human alpha globin upstream regulatory element (HS-40) in transgenic mice." @default.
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