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- W835644673 abstract "To study vitamin A (VA) metabolism in infants, a tracer dose of [13C10]-retinyl acetate was given orally to 15 subjects (15-34 months), 2 samples were drawn/child to build a 10 time-point kinetic curve from 7.5 h to 35 d after dosing; mean fraction of dose in plasma was calculated at each sampling time. Model-based compartmental analysis using WinSAAM was used to develop a composite 'super-kid’ model of plasma [13C10]-retinol kinetics. Data fit a 5 compartment model which includes a delay element representing VA digestion and absorption plus chylomicron formation and metabolism; a compartment for uptake and metabolism of newly absorbed VA in liver; the plasma retinol pool; and two extravascular VA storage pools: a fast- and a slower turning-over compartment. Irreversible loss was modeled from the slower turning-over pool, at a rate of 2.6% per day, which is the system fractional catabolic rate (FCR). Our modeling results indicate early and rapid VA absorption, followed by significant retinol recycling among plasma and tissues and high retinol turnover, plus a low system FCR reflecting the relatively high VA stores in these well-nourished infants who received a 60 mg retinyl acetate dose as part of a National Program in Mexico, 3 mo prior to this study. The 'super kid’ approach facilitates model development in infants for whom blood collections need to be minimized or when access to subjects is limited in the field. IAEA 16880" @default.
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- W835644673 date "2015-04-01" @default.
- W835644673 modified "2023-09-23" @default.
- W835644673 title "Development of a “Super‐Kid” Model Based on Plasma [ <sup>13</sup> c <sub>10</sub> ]‐Retinol Kinetics in Well‐Nourished Mexican Infants" @default.
- W835644673 doi "https://doi.org/10.1096/fasebj.29.1_supplement.604.11" @default.
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