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• W835984114 abstract "Hernia inguinalis/scrotalis (i/s) in pigs are known as congenital defects which occur with a frequency of 1-3% and a heritability of h2 = 0.02 to h2 = 0.86 in German pig breeds and cause enormous economic losses.Therefore, the elucidation of the mode of inheritance and the development of DNA based tests are of crucial economic and scientific concern.At the Institute of Veterinary Medicine (IVM) the studies of the genetic basis of Hernia (i/s) take place within the national research project Entwicklung von Techniken und Methoden zur Kartierung von Defektgenen beim Schwein .In the present study, we determined the calcium contents in peritoneal tissue samples and samples of the Processus vaginalis of piglets which were associated with Hernia (i/s). Our results showed a significant difference of the calcium content of tissue samples collected from the reproduction tract between the tissue samples obtained from affected animals compared to those of normal healthy pigs.Due to these results - and additionally based on the results of a genome wide linkage scan, which was carried out at the IVM we mapped functional candidate genes to porcine chromosomes (Sus scrofa chromosome, SSC) 3, 6, 7 and 15 which we additionally considered to be positional candidates. These candidate genes, which are supposed to be associated with Hernia (i/s) play an important role in the calcium homeostasis and within the apoptotic cascade. Furthermore, polymorphic microsatellites were detected within these candidate genes by target oligonucleotide mediated microsatellite identification (TOMMI) and tested in a population of affected pig families." @default.
• W835984114 created "2016-06-24" @default.
• W835984114 creator A5050027426 @default.
• W835984114 date "2022-02-20" @default.
• W835984114 modified "2023-10-14" @default.
• W835984114 title "Molekulargenetische und physiologische Untersuchungen zur Vererbung des Erbdefektes Hernia inguinalis/scrotalis beim Schwein" @default.
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• W835984114 doi "https://doi.org/10.53846/goediss-1883" @default.
• W835984114 hasPublicationYear "2022" @default.
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