Matches in SemOpenAlex for { <https://semopenalex.org/work/W836431074> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W836431074 endingPage "180" @default.
- W836431074 startingPage "173" @default.
- W836431074 abstract "The effects of agmatine on the enzymes responsible for the biosynthesis of polyamines, the resultant levels of polyamines, and their effect on the growth of DU145 human prostate tumor cells were investigated. When agmatine was added to the medium, ornithine decarboxylase (ODC, EC 4.1.1.17) activity was substantially reduced, but S-adenosylmethionine decarboxylase (SAMDC, EC 4.1.1.50) activity increased markedly. These changes in ODC and SAMDC activities were the result of an induction of ODC-antizyme and a decreased turnover rate of SAMDC in the presence of agmatine. Accordingly, there was a decrease in the intracellular levels of putrescine and spermidine but an increase in the intracellular level of spermine. Cell growth was markedly inhibited by agmatine treatment and this inhibition was not recovered by the addition of putrescine or spermidine. Our results suggest that agmatine alters the intracellular amounts of polyamine in the cells, closely related to the inhibition of cell growth." @default.
- W836431074 created "2016-06-24" @default.
- W836431074 creator A5008373719 @default.
- W836431074 creator A5029799745 @default.
- W836431074 date "1999-01-01" @default.
- W836431074 modified "2023-09-23" @default.
- W836431074 title "Effects of Agmatine on Polyamine Metabolism and the Growth of Prostate Tumor Cells" @default.
- W836431074 hasPublicationYear "1999" @default.
- W836431074 type Work @default.
- W836431074 sameAs 836431074 @default.
- W836431074 citedByCount "0" @default.
- W836431074 crossrefType "journal-article" @default.
- W836431074 hasAuthorship W836431074A5008373719 @default.
- W836431074 hasAuthorship W836431074A5029799745 @default.
- W836431074 hasConcept C108905728 @default.
- W836431074 hasConcept C121289238 @default.
- W836431074 hasConcept C181199279 @default.
- W836431074 hasConcept C185592680 @default.
- W836431074 hasConcept C2776109719 @default.
- W836431074 hasConcept C2777107663 @default.
- W836431074 hasConcept C2777167505 @default.
- W836431074 hasConcept C2777497464 @default.
- W836431074 hasConcept C2780115381 @default.
- W836431074 hasConcept C2781448169 @default.
- W836431074 hasConcept C55493867 @default.
- W836431074 hasConcept C62112901 @default.
- W836431074 hasConcept C79879829 @default.
- W836431074 hasConcept C86803240 @default.
- W836431074 hasConceptScore W836431074C108905728 @default.
- W836431074 hasConceptScore W836431074C121289238 @default.
- W836431074 hasConceptScore W836431074C181199279 @default.
- W836431074 hasConceptScore W836431074C185592680 @default.
- W836431074 hasConceptScore W836431074C2776109719 @default.
- W836431074 hasConceptScore W836431074C2777107663 @default.
- W836431074 hasConceptScore W836431074C2777167505 @default.
- W836431074 hasConceptScore W836431074C2777497464 @default.
- W836431074 hasConceptScore W836431074C2780115381 @default.
- W836431074 hasConceptScore W836431074C2781448169 @default.
- W836431074 hasConceptScore W836431074C55493867 @default.
- W836431074 hasConceptScore W836431074C62112901 @default.
- W836431074 hasConceptScore W836431074C79879829 @default.
- W836431074 hasConceptScore W836431074C86803240 @default.
- W836431074 hasIssue "2" @default.
- W836431074 hasLocation W8364310741 @default.
- W836431074 hasOpenAccess W836431074 @default.
- W836431074 hasPrimaryLocation W8364310741 @default.
- W836431074 hasRelatedWork W1496546960 @default.
- W836431074 hasRelatedWork W1573955016 @default.
- W836431074 hasRelatedWork W1971509042 @default.
- W836431074 hasRelatedWork W1974876724 @default.
- W836431074 hasRelatedWork W1975142810 @default.
- W836431074 hasRelatedWork W2013518049 @default.
- W836431074 hasRelatedWork W2037089642 @default.
- W836431074 hasRelatedWork W2049873650 @default.
- W836431074 hasRelatedWork W2057977602 @default.
- W836431074 hasRelatedWork W2065183634 @default.
- W836431074 hasRelatedWork W2073918561 @default.
- W836431074 hasRelatedWork W2090693384 @default.
- W836431074 hasRelatedWork W2092657673 @default.
- W836431074 hasRelatedWork W2093236249 @default.
- W836431074 hasRelatedWork W2235720177 @default.
- W836431074 hasRelatedWork W2240976091 @default.
- W836431074 hasRelatedWork W2413206150 @default.
- W836431074 hasRelatedWork W2413825106 @default.
- W836431074 hasRelatedWork W3161951378 @default.
- W836431074 hasRelatedWork W47732198 @default.
- W836431074 hasVolume "32" @default.
- W836431074 isParatext "false" @default.
- W836431074 isRetracted "false" @default.
- W836431074 magId "836431074" @default.
- W836431074 workType "article" @default.