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- W8371303 abstract "Pharmacologically, a decrease in sinus heart rate can be achieved by several means: indirectly, via inhibition of the autonomic nervous system, and directly at the pacemaker cells of the atrial sinus node. The term “Specific Bradycardic Agents” has been proposed for drugs which directly decrease the sinus rate in doses or concentrations smaller than are necessary to elicit other pharmacological effects [1, 7, 9, 10, 13]. ULFS 49 CL is such a new, specific, negative chronotropic agent which directly decreases the spontaneous heart rate by slowing the diastolic depolarization of the pacemaker cells in the sinu-atrial node [6, 8, 11]." @default.
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- W8371303 date "1991-01-01" @default.
- W8371303 modified "2023-09-28" @default.
- W8371303 title "Electrophysiological effects of ULFS 49 CL" @default.
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- W8371303 doi "https://doi.org/10.1007/978-3-642-72458-9_4" @default.
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