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- W837250010 abstract "Cytoplasmic dynein is a molecular motor that drives cargoes, including whole organelles such as mitochondria, from the periphery of the cell to the perinuclear region by using microtubules as railroad tracks. In Neurons, Dynein is involved in retrograde axonal transport, which is a process required for neurons survival. Alterations in axonal transport, in both anterograde and retrograde axonal transport, were found in neurodegenerative diseases. This thesis work aims at showing that an axonal transport alteration is not sufficient to induce motor neuron disease (Dupuis, 2009), but sufficient to provoke a striatal dysfunction (Braunstein, 2010). Besides this neuronal aspect, dynein seems to be involved in lipids metabolism since dynein mutant mice present also a metabolic phenotype. Indeed, they showed an increase of fat mass in correlation with age due to a defective lipolysis associated with an increase oxidative stress (Eschbach, 2011). In parallel, we observed that dynein is required for the mitochondrial functions (manuscript ongoing). Finally, we determined the mechanisms of protective effect of dynein mutation in ALS mice (Fergani, 2011). In conclusion, this thesis work aims at showing that an axonal transport alteration is not sufficient to induce motor neuron disease, but sufficient to provoke a striatal dysfunction. Concerning the white adipose tissue, dynein seems to be involved in the lipolysis process. In addition, our results suggest that dynein is required for the mitochondrial function. Our current hypothesis is that this mitochondrial dysfunction could provoke the observed phenotype in both striatum and adipose tissue." @default.
- W837250010 created "2016-06-24" @default.
- W837250010 creator A5064302200 @default.
- W837250010 date "2011-01-01" @default.
- W837250010 modified "2023-09-27" @default.
- W837250010 title "Caractérisation de la fonction in vivo de la dynéine cytoplasmique par l'utilisation de souris mutantes" @default.
- W837250010 hasPublicationYear "2011" @default.
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