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• W837449850 abstract "Mutations in genes that encode chemokines and chemokine receptors have been implicated in host susceptibility to human immunodeficiency virus-1 (HIV-1) infection, and subsequent progression to acquired immunodeficiency syndrome (AIDS). More recently, the associations between these genetic variants and HIV-1/AIDS pathogenesis have emerged as being population-specific. Limited research exists on the effects of previously reported HIV-1/AIDS-associated polymorphisms in African-based ethnic groups, particularly those residing in the pandemic-stricken regions of the world. This prompted our case-control study of Sub-Saharan Africans of Xhosa descent, consisting of 215 HIV-1 seropositive and 113 HIV-1 seronegative individuals. We screened CCR5, CCR2, CX3CR1 and CCL5 (RANTES), with significance being observed for three single nucleotide polymorphisms (SNPs), including CCR5-2733A>G, CCR5-2135C>T and CX3CR1V249I (G>A). The CCR5-2733 G allele (P = 0.0409) together with the heterozygous genotype, CCR5-2733 AG (P = 0.0270), was associated with a reduced risk for HIV-1 infection. The CX3CR1249I allele (P = 0.0479) was also associated with reduced risk to HIV-1 infection. The opposite was observed for the CCR5-2135 T allele (P = 0.0024) and homozygosity for CCR5-2135 TT (P = 0.0096), which were associated with increased susceptibility to HIV-1 infection. All these associations with susceptibility to HIV-1 infection appear to be unique to the Xhosa ethnic group. This result emphasises the importance of elucidating the specific effect of known HIV-1/AIDS candidate gene variants in understudied populations." @default.
• W837449850 created "2016-06-24" @default.
• W837449850 creator A5018683529 @default.
• W837449850 date "2006-12-01" @default.
• W837449850 modified "2023-09-27" @default.
• W837449850 title "Genetic aspects of HIV-1 risk in an African setting" @default.
• W837449850 cites W1483737778 @default.
• W837449850 cites W1512118356 @default.
• W837449850 cites W1537629327 @default.
• W837449850 cites W1544307647 @default.
• W837449850 cites W1551351100 @default.
• W837449850 cites W1582855350 @default.
• W837449850 cites W1594564120 @default.
• W837449850 cites W1596604198 @default.
• W837449850 cites W1606330082 @default.
• W837449850 cites W1607270055 @default.
• W837449850 cites W163011789 @default.
• W837449850 cites W1664162846 @default.
• W837449850 cites W1678073641 @default.
• W837449850 cites W1799513092 @default.
• W837449850 cites W1830462044 @default.
• W837449850 cites W1862745872 @default.
• W837449850 cites W1891735350 @default.
• W837449850 cites W1911746360 @default.
• W837449850 cites W1911887288 @default.
• W837449850 cites W192202107 @default.
• W837449850 cites W1963984954 @default.
• W837449850 cites W1965019797 @default.
• W837449850 cites W1966386267 @default.
• W837449850 cites W1967939390 @default.
• W837449850 cites W1968057545 @default.
• W837449850 cites W1969176674 @default.
• W837449850 cites W1970697066 @default.
• W837449850 cites W1973425803 @default.
• W837449850 cites W1974083313 @default.
• W837449850 cites W1974132609 @default.
• W837449850 cites W1974938982 @default.
• W837449850 cites W1977998462 @default.
• W837449850 cites W1979365074 @default.
• W837449850 cites W1979442735 @default.
• W837449850 cites W1980539061 @default.
• W837449850 cites W1981440980 @default.
• W837449850 cites W1981644527 @default.
• W837449850 cites W1983988906 @default.
• W837449850 cites W1984811742 @default.
• W837449850 cites W1984899683 @default.
• W837449850 cites W1985055932 @default.
• W837449850 cites W1985943658 @default.
• W837449850 cites W1986143942 @default.
• W837449850 cites W1986574361 @default.
• W837449850 cites W1987802717 @default.
• W837449850 cites W1989035987 @default.
• W837449850 cites W1989701896 @default.
• W837449850 cites W1990139289 @default.
• W837449850 cites W1991016287 @default.
• W837449850 cites W1992031335 @default.
• W837449850 cites W1992830524 @default.
• W837449850 cites W1992969547 @default.
• W837449850 cites W1993717446 @default.
• W837449850 cites W1994173489 @default.
• W837449850 cites W1995571181 @default.
• W837449850 cites W1996183144 @default.
• W837449850 cites W1996220604 @default.
• W837449850 cites W1997453592 @default.
• W837449850 cites W1998015678 @default.
• W837449850 cites W2000625134 @default.
• W837449850 cites W2001756249 @default.
• W837449850 cites W2006289223 @default.
• W837449850 cites W2006619058 @default.
• W837449850 cites W2007551467 @default.
• W837449850 cites W2009104414 @default.
• W837449850 cites W2010068219 @default.
• W837449850 cites W2010200226 @default.
• W837449850 cites W2010995683 @default.
• W837449850 cites W2015525697 @default.
• W837449850 cites W2018984903 @default.
• W837449850 cites W2019636581 @default.
• W837449850 cites W2020396133 @default.
• W837449850 cites W2022852420 @default.
• W837449850 cites W2023878269 @default.
• W837449850 cites W2024702568 @default.
• W837449850 cites W2025797490 @default.
• W837449850 cites W2026444780 @default.
• W837449850 cites W2027992442 @default.
• W837449850 cites W2028156913 @default.
• W837449850 cites W2028866370 @default.
• W837449850 cites W2029083442 @default.
• W837449850 cites W2031089158 @default.
• W837449850 cites W2031433110 @default.
• W837449850 cites W2031660981 @default.
• W837449850 cites W2033974974 @default.
• W837449850 cites W2034428861 @default.
• W837449850 cites W2034908449 @default.
• W837449850 cites W2036652038 @default.
• W837449850 cites W2038048329 @default.
• W837449850 cites W2039073504 @default.
• W837449850 cites W2039511189 @default.
• W837449850 cites W2040309911 @default.
• W837449850 cites W2042736878 @default.
• W837449850 cites W2043541788 @default.

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