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- W83773349 abstract "The dynamic interaction between malignant melanoma cells and the host’s immune system has a profound influence on the development and progression of disease. Numerous studies have documented the therapeutic potential of immunological manipulation in patients with melanoma, and many tumorassociated antigens have been studied as possible targets of melanoma-specific immunotherapy. This chapter outlines the most significant melanoma-associated antigens, highlighting those with the greatest potential for influencing future treatment modalities. Specific antigens defined by T- and B-cells are discussed, and how these antigens are recognized, processed, and manipulated by the host’s immune system is explained. The role of gangliosides in distinguishing different stages of melanocyte differentiation is described, and a 90-kDa tumor-associated glycoprotein antigen which has considerable promise as a marker of melanoma tumor burden is introduced. Finally, this chapter reviews technological advances in assays used to detect various melanoma-associated antigens.Key WordsMelanomamelanoma-associated antigenstumor-associated antigensimmunotherapyTA90" @default.
- W83773349 created "2016-06-24" @default.
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- W83773349 creator A5023433820 @default.
- W83773349 creator A5029428307 @default.
- W83773349 date "2007-11-04" @default.
- W83773349 modified "2023-09-25" @default.
- W83773349 title "Role of Melanoma-Associated Antigens" @default.
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- W83773349 doi "https://doi.org/10.1007/978-1-59259-994-3_35" @default.
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