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• W83974815 abstract "ABSTRACT ADPglucose (ADPG) pyrophosphorylase catalyzes the biosynthesis of ADPglucose from ATP and α-glucose-1-P and is the first unique enzyme in the bacterial glycogen and plant starch biosynthetic pathways. It is activated by glycolytic intermediates in most if not all bacterial and plant extracts and may be inhibited by 5′-AMP, ADP and/or P i (see Preiss, J., in Adv. in Enzymol., Vol. 46, pp. 317-381 (1978)). The major activators are pyruvate (usually observed for the photosynthetic bacterial enzyme), 3-P-glycerate (the major activator for the higher plant, algal and blue green bacterial ADPG pyrophosphorylases), fructose-6-P and fructose-P 2 . The last two activators are usually observed for ADPG pyrophosphorylases from bacteria that catabolize sugars via the Entner Doudoroff and glycolytic pathways, respectively. Thus, the activator specificity of the bacterial and plant ADPglucose pyrophosphorylases roughly correlates with the ability of the organism to metabolize various carbon sources for energy and growth. The activator specificity may also be used in certain classes of organisms as a taxonomic marker. Causal data with plants and bacteria correlating fluctuation of inhibitor and activator concentrations in vivo with rates of α-glucan synthesis strongly suggest that the activator and inhibitor effects observed in vitro are physiologically operative. Furthermore isolation of a class of mutants of E. coli and S. typhimurium altered in their ability to accumulate α-glucan can be correlated with altered affinities of the inhibitor AMP and the activator, fructose-P 2 for the organism's ADPglucose pyrophosphorylase. Covalent attachment of [ 3 H] pyridoxal-P (PLP) to the activator binding site of the E. coli enzyme has enabled us to determine the amino acid sequence around the activator site and determine it to be a lysyl residue 37 amino acid residues from the amino-terminus of the enzyme. The sequence is: NH 2 -Val-Ser-Leu-Glu-Lys-Asn-Asp-His-Leu-Met-Leu-Ala-Arg-Gln-Leu-Pro-Leu-Lys-Ser-Val-Ala-Leu-Ile-Leu-Ala-Gly-Gly-Arg-Gly-Thr-Arg-Leu-Lys-Asp-Leu-Thr-Asn-Lys-(PLP)-Arg-Ala-Lys-Pro-Ala-Val-His-Phe-Gly-Gly-Lys…." @default.
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• W83974815 date "1979-01-01" @default.
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• W83974815 title "COMPARATIVE REGULATION OF α1, 4-GLUCAN SYNTHESIS IN PHOTOSYNTHETIC AND NON-PHOTOSYNTHETIC SYSTEMS" @default.
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• W83974815 doi "https://doi.org/10.1016/b978-0-12-066250-0.50014-4" @default.
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