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- W83997752 abstract "Conjugated linoleic acid (CLA) and n-3 fatty acids (FA) have been proposed as an important pharmaconutrient for modulating cancer and obesity. We investigated effect of CLA and n-3 FA alone or in combination to modulate bone loss and liver steaotosis in aging C57Bl/6 mice. Twelve months old C57Bl/6 mice were fed with 10% corn oil (CO) as control, with or without 0.5 % CLA (50:50 mixture of c9t11 and t10c12 isomers), 5% n-3 FA and a combination of 0.5 % CLA and 5% n-3 FA for 6 months. After 6 months dietary intervention, CLA and CLA+n-3 FA fed mice reduced body weight and maintained bone mineral density compared to CO group. Importantly, CLA induced liver hypertrophy or steatosis was completely prevented by incorporation of n- 3 FA in CLA diet. The liver histology revealed that lipid filled vacuoles were significantly less in n-3 FA and CLA+n-3 FA diet fed mice compared to CO and CLA fed mice. The inherited property of n-3 FA to reduce triglycerides may be responsible in modulating the liver hypertrophy induced by CLA. The DXA results showed that CLA and CLA+n-3 FA diet also increased the lean mass in the hind leg. Furthermore, femoral bone histological sections stained with oil red O showed that CLA and CLA+n-3 FA diet prevented bone adiposity. These findings demonstrate that CLA with n-3 FA can be used for obesity as well as osteoporosis prevention strategy. Further studies in higher species and humans are needed to confirm this observation. Research support: NIH R21 AG027562" @default.
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- W83997752 date "2009-04-01" @default.
- W83997752 modified "2023-09-24" @default.
- W83997752 title "Effect of conjugated linoleic acid and n‐3 fatty acids on body composition and bone loss in aging C57Bl/6 mice" @default.
- W83997752 doi "https://doi.org/10.1096/fasebj.23.1_supplement.543.4" @default.
- W83997752 hasPublicationYear "2009" @default.
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