Matches in SemOpenAlex for { <https://semopenalex.org/work/W840515943> ?p ?o ?g. }
- W840515943 endingPage "330" @default.
- W840515943 startingPage "318" @default.
- W840515943 abstract "The objective of the study is to fabricate multifunctional mesoporous silica nanoparticles for achieving co-delivery of conventional antitumor drug paclitaxel (PTX) and the multidrug resistance reversal agent tetrandrine (TET) expecting to overcome multidrug resistance of MCF-7/ADR cells. The nanoparticles were facile to prepare by self-assemble in situ drug loading approach. Namely, PTX and TET were solubilized in the cetyltrimethylammonium bromide (CTAB) micelles and simultaneously silica resources hydrolyze and condense to form nanoparticles. The obtained nanoparticles, denoted as PTX/TET-CTAB@MSN, exhibited pH-responsive release property with more easily released in the weak acidic environment. Studies on cellular uptake of nanoparticles demonstrated TET could markedly increase intracellular accumulation of nanoparticles. Furthermore, the PTX/TET-CTAB@MSN suppressed tumor cells growth more efficiently than only delivery of PTX (PTX-CTAB@MSN) or the free PTX. Moreover, the nanoparticle loading drugs with a PTX/TET molar ratio of 4.4:1 completely reversed the resistance of MCF-7/ADR cells to PTX and the resistance reversion index was 72.3. Mechanism research showed that both TET and CTAB could arrest MCF-7/ADR cells at G1 phase; and besides PTX arrested cells at G2 phase. This nanocarrier might have important potential in clinical implications for co-delivery of multiple drugs to overcome MDR." @default.
- W840515943 created "2016-06-24" @default.
- W840515943 creator A5002339150 @default.
- W840515943 creator A5008795836 @default.
- W840515943 creator A5042688500 @default.
- W840515943 creator A5043000448 @default.
- W840515943 creator A5051769353 @default.
- W840515943 creator A5069649067 @default.
- W840515943 creator A5090698080 @default.
- W840515943 date "2015-07-01" @default.
- W840515943 modified "2023-10-02" @default.
- W840515943 title "Multifunctional mesoporous silica nanoparticles mediated co-delivery of paclitaxel and tetrandrine for overcoming multidrug resistance" @default.
- W840515943 cites W1474183708 @default.
- W840515943 cites W1857799540 @default.
- W840515943 cites W1973509266 @default.
- W840515943 cites W1976251743 @default.
- W840515943 cites W1978932462 @default.
- W840515943 cites W1981267478 @default.
- W840515943 cites W1987885263 @default.
- W840515943 cites W1991914198 @default.
- W840515943 cites W1995220749 @default.
- W840515943 cites W1996921023 @default.
- W840515943 cites W2006434892 @default.
- W840515943 cites W2015704490 @default.
- W840515943 cites W2017239698 @default.
- W840515943 cites W2022449296 @default.
- W840515943 cites W2025141250 @default.
- W840515943 cites W2032336447 @default.
- W840515943 cites W2034829647 @default.
- W840515943 cites W2035045849 @default.
- W840515943 cites W2036261157 @default.
- W840515943 cites W2037012457 @default.
- W840515943 cites W2044154925 @default.
- W840515943 cites W2049027943 @default.
- W840515943 cites W2062061194 @default.
- W840515943 cites W2063825168 @default.
- W840515943 cites W2070753546 @default.
- W840515943 cites W2072554913 @default.
- W840515943 cites W2073055302 @default.
- W840515943 cites W2075656767 @default.
- W840515943 cites W2077382185 @default.
- W840515943 cites W2087281835 @default.
- W840515943 cites W2087432084 @default.
- W840515943 cites W2087483515 @default.
- W840515943 cites W2088391278 @default.
- W840515943 cites W2099079698 @default.
- W840515943 cites W2102819518 @default.
- W840515943 cites W2136510151 @default.
- W840515943 cites W2153666475 @default.
- W840515943 cites W2155385159 @default.
- W840515943 cites W2160771041 @default.
- W840515943 cites W2167806590 @default.
- W840515943 cites W2312596526 @default.
- W840515943 cites W2317217839 @default.
- W840515943 cites W4231136244 @default.
- W840515943 doi "https://doi.org/10.1016/j.ijpharm.2015.05.010" @default.
- W840515943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25956050" @default.
- W840515943 hasPublicationYear "2015" @default.
- W840515943 type Work @default.
- W840515943 sameAs 840515943 @default.
- W840515943 citedByCount "78" @default.
- W840515943 countsByYear W8405159432015 @default.
- W840515943 countsByYear W8405159432016 @default.
- W840515943 countsByYear W8405159432017 @default.
- W840515943 countsByYear W8405159432018 @default.
- W840515943 countsByYear W8405159432019 @default.
- W840515943 countsByYear W8405159432020 @default.
- W840515943 countsByYear W8405159432021 @default.
- W840515943 countsByYear W8405159432022 @default.
- W840515943 countsByYear W8405159432023 @default.
- W840515943 crossrefType "journal-article" @default.
- W840515943 hasAuthorship W840515943A5002339150 @default.
- W840515943 hasAuthorship W840515943A5008795836 @default.
- W840515943 hasAuthorship W840515943A5042688500 @default.
- W840515943 hasAuthorship W840515943A5043000448 @default.
- W840515943 hasAuthorship W840515943A5051769353 @default.
- W840515943 hasAuthorship W840515943A5069649067 @default.
- W840515943 hasAuthorship W840515943A5090698080 @default.
- W840515943 hasConcept C11268172 @default.
- W840515943 hasConcept C12554922 @default.
- W840515943 hasConcept C133936738 @default.
- W840515943 hasConcept C141071460 @default.
- W840515943 hasConcept C155672457 @default.
- W840515943 hasConcept C161790260 @default.
- W840515943 hasConcept C171250308 @default.
- W840515943 hasConcept C178790620 @default.
- W840515943 hasConcept C18150654 @default.
- W840515943 hasConcept C184651966 @default.
- W840515943 hasConcept C185592680 @default.
- W840515943 hasConcept C192562407 @default.
- W840515943 hasConcept C2776694085 @default.
- W840515943 hasConcept C2777292972 @default.
- W840515943 hasConcept C2777496208 @default.
- W840515943 hasConcept C2779820397 @default.
- W840515943 hasConcept C2779934757 @default.
- W840515943 hasConcept C501593827 @default.
- W840515943 hasConcept C55493867 @default.
- W840515943 hasConcept C71924100 @default.