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- W84051837 abstract "Tendon and ligament damage causes extreme pain and decreased joint functionality. Current repair methods cannot restore original joint biomechanics nor promote regeneration of native tissue. Recent advances in tendon and ligament repair have involved engineering tissue using cell-seeded scaffolds. Self-aligned cellular structures, similar to those in ligaments and tendons, have been successfully formed, albeit with weak attachment between construct and bone. Calcium phosphates form an intimate bond with both soft and hard tissues and have successfully been used in tissue engineering bone, whilst hydrogels have often been used as cellular scaffolds. This thesis explores agarose, gelatin, carrageenan and fibrin hydrogels as potential soft tissue scaffolds. Fibrin gel exhibited high cellular compatibility with highest metabolic activity on day 14. Although the cellular gel contracted significantly, it was found that the dry weight remained stable in both the acellular and cellular forms. 3D powder printed calcium phosphate scaffolds remained structurally stable after immersion in cell culture media with immersion in protein-rich sera promoting tenocyte attachment. Bracket designs were developed to enhance grip of the cell-seeded fibrin. Ligament constructs were selfsupporting and exhibited structural characteristics similar to native connective tissue. Tenocyte density peaked on day 14, with added L-proline and ascorbic acid inducing a constant level of glycosaminoglycans and 7.4 ± 1.5 % w/w collagen. This research may significantly enhance the clinical application of tissue engineered ligaments and tendons." @default.
- W84051837 created "2016-06-24" @default.
- W84051837 creator A5056232100 @default.
- W84051837 date "2011-12-01" @default.
- W84051837 modified "2023-09-27" @default.
- W84051837 title "Tissue engineering a ligamentous construct" @default.
- W84051837 cites W108042802 @default.
- W84051837 cites W1126201824 @default.
- W84051837 cites W118422671 @default.
- W84051837 cites W1225575464 @default.
- W84051837 cites W1234150780 @default.
- W84051837 cites W1481518948 @default.
- W84051837 cites W149074297 @default.
- W84051837 cites W1491995592 @default.
- W84051837 cites W1498725839 @default.
- W84051837 cites W1502648774 @default.
- W84051837 cites W1522548947 @default.
- W84051837 cites W1529214549 @default.
- W84051837 cites W1581880305 @default.
- W84051837 cites W1587016963 @default.
- W84051837 cites W165905914 @default.
- W84051837 cites W1771305035 @default.
- W84051837 cites W1875588079 @default.
- W84051837 cites W1963635572 @default.
- W84051837 cites W1963698651 @default.
- W84051837 cites W1965134787 @default.
- W84051837 cites W1966148180 @default.
- W84051837 cites W1967599454 @default.
- W84051837 cites W1969221269 @default.
- W84051837 cites W1969568402 @default.
- W84051837 cites W1969733925 @default.
- W84051837 cites W1970576706 @default.
- W84051837 cites W1970967229 @default.
- W84051837 cites W1973722837 @default.
- W84051837 cites W1973756460 @default.
- W84051837 cites W1974690659 @default.
- W84051837 cites W1974820990 @default.
- W84051837 cites W1976006167 @default.
- W84051837 cites W1976377404 @default.
- W84051837 cites W1978566475 @default.
- W84051837 cites W1978651811 @default.
- W84051837 cites W1979516244 @default.
- W84051837 cites W1979578063 @default.
- W84051837 cites W1980688341 @default.
- W84051837 cites W1981183215 @default.
- W84051837 cites W1981760485 @default.
- W84051837 cites W1982172071 @default.
- W84051837 cites W1983157851 @default.
- W84051837 cites W1983762554 @default.
- W84051837 cites W1984277999 @default.
- W84051837 cites W1984729535 @default.
- W84051837 cites W1984878710 @default.
- W84051837 cites W1985140092 @default.
- W84051837 cites W1985204201 @default.
- W84051837 cites W1985746633 @default.
- W84051837 cites W1985747008 @default.
- W84051837 cites W1986300999 @default.
- W84051837 cites W1986968030 @default.
- W84051837 cites W1987190449 @default.
- W84051837 cites W1988106932 @default.
- W84051837 cites W1988147327 @default.
- W84051837 cites W1989191180 @default.
- W84051837 cites W1990092484 @default.
- W84051837 cites W1990439612 @default.
- W84051837 cites W1990851605 @default.
- W84051837 cites W1996623365 @default.
- W84051837 cites W1997068847 @default.
- W84051837 cites W1998587582 @default.
- W84051837 cites W1999277351 @default.
- W84051837 cites W2000465858 @default.
- W84051837 cites W2000488306 @default.
- W84051837 cites W2001274495 @default.
- W84051837 cites W2001467937 @default.
- W84051837 cites W2001973848 @default.
- W84051837 cites W2002201300 @default.
- W84051837 cites W2003523068 @default.
- W84051837 cites W2003884649 @default.
- W84051837 cites W2004282319 @default.
- W84051837 cites W2004487633 @default.
- W84051837 cites W2004710891 @default.
- W84051837 cites W2005317105 @default.
- W84051837 cites W2005611861 @default.
- W84051837 cites W2005909933 @default.
- W84051837 cites W2006380736 @default.
- W84051837 cites W2008029193 @default.
- W84051837 cites W2011465381 @default.
- W84051837 cites W2011498196 @default.
- W84051837 cites W2012222854 @default.
- W84051837 cites W2013035214 @default.
- W84051837 cites W2013180292 @default.
- W84051837 cites W2013361845 @default.
- W84051837 cites W2013459939 @default.
- W84051837 cites W2013632655 @default.
- W84051837 cites W2014278600 @default.
- W84051837 cites W2015996457 @default.
- W84051837 cites W2016484384 @default.
- W84051837 cites W2016583814 @default.
- W84051837 cites W2016726612 @default.
- W84051837 cites W2016799899 @default.
- W84051837 cites W2017056944 @default.