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- W84095940 abstract "Publisher Summary This chapter presents the characterization and the tissue distribution of anticoagulant heparan sulfate proteoglycans (aHSPGs) in female reproductive tract. It also discusses the emerging role of aHSPGs in the control of tissue remodeling in reproduction. HSPGs are ubiquitously distributed on the surfaces of animal cells and in the extracellular matrix. They have numerous important biological activities through interactions with diverse proteins. HSPGs are composed of a core protein with covalently attached HS chains formed by repetitive sulfated disaccharides of uronic acid and glucosamine (GlcN). The AT-binding pentasaccharide of heparin (HP) and anticoagulant HS (aHS) is the best characterized biologically active structure of HS. It specifically binds and activates AT by inducing a conformational change in the inhibitor that stabilizes its active conformer. Endothelial aHSPGs are thought to endow the vascular wall with antithrombotic properties, particularly in the subendothelial basement membrane. aHSPG were detected on cell surfaces as well as in soluble form in cell-conditioned medium showing that aHSPGs can be released from the cell surface by secretion or by shedding their extracellular domain." @default.
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- W84095940 date "2005-01-01" @default.
- W84095940 modified "2023-10-16" @default.
- W84095940 title "Role of Anticoagulant Heparan Sulfate in Mammalian Reproduction" @default.
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- W84095940 doi "https://doi.org/10.1016/b978-008044859-6/50016-2" @default.
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