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• W84121270 abstract "The study is to evaluate the potential of ethanolic ext ract of Moringa oleifera (EEM O) in ameliorating biochemical ano malies associated with Non-Alcoholic Fatty Liver Disease (NAFLD). Rats were fed 5 ml of h igh fat emu lsion (HFE) for three weeks to induce NAFLD. Rats in Groups 3,4,5,and 6 were ad ministered 5ml of high fat emu lsion (HFE) daily for 3 weeks and subsequently administered 100, 200, 300 mg/ kg of EEMO and 30 mg/kg pioglitazone (PG) respectively. NAFLD induction resulted in significant increase in hepatic and seru m triacylg lycerols (TA G) and cholesterol (CHOL) levels when co mpared with control, wh ile treat ment with EEMO resulted in significant reduction. NAFLD induction had no significant effects on hepatic reduced glutathione (GSH) and catalase activity. There was a significant increase in activity of Supero xide Dis mutase (SOD) and malondialdehyde (MDA) level, signify ing the existence of hepatic lipid peroxidation. There was also a significant increase in Ho meostasis Model Assessment for insulin resistance (HOMA-IR), serum insulin and fasting blood glucose (FBG) levels, suggesting diminished insulin sensitivity. Admin istration of EEM O resulted in decrease SOD act ivity in a dose dependent fashion when compared with FBG. A similar effect was seen with the levels of MDA, insulin, FBG and HOMA-IR. These findings suggest that EEM O imp rov es the hepatic status of animals with NAFLD ." @default.
• W84121270 created "2016-06-24" @default.
• W84121270 creator A5054350893 @default.
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• W84121270 date "2013-01-01" @default.
• W84121270 modified "2023-09-27" @default.
• W84121270 title "Amelioration of Hepatic Lipid Peroxidation and Insulin Sensitivity by an Ethanolic Extract of Moringa o leif era in Non-Alcoholic Fatty Liver Disease (NAFLD) in Rats" @default.
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