Matches in SemOpenAlex for { <https://semopenalex.org/work/W841308424> ?p ?o ?g. }
- W841308424 endingPage "456" @default.
- W841308424 startingPage "447" @default.
- W841308424 abstract "Abstract Methods to monitor the metabolic transformations of pharmaceuticals in a real-time and rapid fashion are required to develop safe and effective drugs. Lactone hydrolysis is one of the most important metabolic transformations; it occurs readily in pharmaceuticals containing lactones by both enzymatic and non-enzymatic processes. In this study, a novel strategy that combines three-way excitation–emission-kinetic (EEM-kinetic) fluorescence data with second-order calibration method based on alternating normalization-weighted error (ANWE) algorithm was developed to monitor the lactone hydrolysis of irinotecan (CPT-11). Accurate real-time concentrations together with reasonable resolutions of the excitation and emission profiles could be estimated for both the lactone form (CPT-11-L) and carboxylate form (CPT-11-C) of CPT-11 during its hydrolysis, even when the fluorescence spectra of CPT-11-L and CPT-11-C seriously overlapped with each other and unknown fluorescent components coexisted in the plasma. Satisfactory results were obtained for static validation samples, spiked plasma samples, and kinetic samples. The average recoveries of CPT-11-L and CPT-11-C in three types of samples mentioned above ranged from 83.7% to 116.7%. The lactone hydrolysis of CPT-11 follows 1st-order degradation kinetics with rate constants of 0.0318 ± 0.0031 min − 1 and 0.0323 ± 0.0008 min − 1 , and half-lives of 21.9 ± 2.0 min and 21.5 ± 0.5 min in PBS and plasma samples, respectively. The strategy described herein minimized or eliminated traditionally time-consuming sample pre-treatments and facilitated the quantification of the target drug in its native environment. This method was proved to be simple, real-time, fast, low-cost, high-efficiency and can be potentially applied to other types of dynamic systems." @default.
- W841308424 created "2016-06-24" @default.
- W841308424 creator A5012278873 @default.
- W841308424 creator A5013054784 @default.
- W841308424 creator A5029742628 @default.
- W841308424 creator A5031777663 @default.
- W841308424 creator A5046881907 @default.
- W841308424 creator A5047135919 @default.
- W841308424 creator A5067057402 @default.
- W841308424 date "2015-08-01" @default.
- W841308424 modified "2023-10-10" @default.
- W841308424 title "Second-order calibration method applied to process three-way excitation–emission-kinetic fluorescence data: A novel tool for real-time quantitative analysis of the lactone hydrolysis of irinotecan in human plasma" @default.
- W841308424 cites W1504006766 @default.
- W841308424 cites W1571918776 @default.
- W841308424 cites W1964339411 @default.
- W841308424 cites W1964796991 @default.
- W841308424 cites W1965551535 @default.
- W841308424 cites W1967988795 @default.
- W841308424 cites W1974715327 @default.
- W841308424 cites W1975616471 @default.
- W841308424 cites W1976106131 @default.
- W841308424 cites W1977922366 @default.
- W841308424 cites W1984259768 @default.
- W841308424 cites W1985858551 @default.
- W841308424 cites W1995772783 @default.
- W841308424 cites W1997735390 @default.
- W841308424 cites W2000274990 @default.
- W841308424 cites W2014665634 @default.
- W841308424 cites W2016227531 @default.
- W841308424 cites W2016926632 @default.
- W841308424 cites W2017573339 @default.
- W841308424 cites W2019867999 @default.
- W841308424 cites W2026678903 @default.
- W841308424 cites W2026707917 @default.
- W841308424 cites W2033602241 @default.
- W841308424 cites W2035305501 @default.
- W841308424 cites W2038268806 @default.
- W841308424 cites W2039632898 @default.
- W841308424 cites W2042321156 @default.
- W841308424 cites W2046772800 @default.
- W841308424 cites W2046821360 @default.
- W841308424 cites W2047680880 @default.
- W841308424 cites W2055957979 @default.
- W841308424 cites W2056371232 @default.
- W841308424 cites W2064198078 @default.
- W841308424 cites W2065104900 @default.
- W841308424 cites W2069753895 @default.
- W841308424 cites W2070534090 @default.
- W841308424 cites W2071029974 @default.
- W841308424 cites W2071115761 @default.
- W841308424 cites W2072533818 @default.
- W841308424 cites W2075485229 @default.
- W841308424 cites W2080899470 @default.
- W841308424 cites W2083053685 @default.
- W841308424 cites W2086179083 @default.
- W841308424 cites W2087702922 @default.
- W841308424 cites W2094220942 @default.
- W841308424 cites W2095973019 @default.
- W841308424 cites W2108899400 @default.
- W841308424 cites W2119196592 @default.
- W841308424 cites W2119741678 @default.
- W841308424 cites W2136282086 @default.
- W841308424 cites W2149563093 @default.
- W841308424 cites W2158932271 @default.
- W841308424 cites W2335684698 @default.
- W841308424 cites W284818195 @default.
- W841308424 cites W2949537065 @default.
- W841308424 cites W38702020 @default.
- W841308424 doi "https://doi.org/10.1016/j.chemolab.2015.06.018" @default.
- W841308424 hasPublicationYear "2015" @default.
- W841308424 type Work @default.
- W841308424 sameAs 841308424 @default.
- W841308424 citedByCount "13" @default.
- W841308424 countsByYear W8413084242016 @default.
- W841308424 countsByYear W8413084242017 @default.
- W841308424 countsByYear W8413084242018 @default.
- W841308424 countsByYear W8413084242019 @default.
- W841308424 countsByYear W8413084242020 @default.
- W841308424 countsByYear W8413084242022 @default.
- W841308424 countsByYear W8413084242023 @default.
- W841308424 crossrefType "journal-article" @default.
- W841308424 hasAuthorship W841308424A5012278873 @default.
- W841308424 hasAuthorship W841308424A5013054784 @default.
- W841308424 hasAuthorship W841308424A5029742628 @default.
- W841308424 hasAuthorship W841308424A5031777663 @default.
- W841308424 hasAuthorship W841308424A5046881907 @default.
- W841308424 hasAuthorship W841308424A5047135919 @default.
- W841308424 hasAuthorship W841308424A5067057402 @default.
- W841308424 hasConcept C105795698 @default.
- W841308424 hasConcept C111919701 @default.
- W841308424 hasConcept C113196181 @default.
- W841308424 hasConcept C119128265 @default.
- W841308424 hasConcept C120665830 @default.
- W841308424 hasConcept C121332964 @default.
- W841308424 hasConcept C165838908 @default.
- W841308424 hasConcept C178790620 @default.
- W841308424 hasConcept C185592680 @default.
- W841308424 hasConcept C186060115 @default.