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- W84202379 abstract "Persons with Down’s syndrome have clonal blood disease more frequently than the general population. Most of the times, these occur with specific characteristics and sometimes may also be a cause of death. The condition known as transient myeloproliferative syndrome stands out. This condition is associated to mutations in the GATA gene and generally of self-limited character. However, this syndrome evolves to acute leukemia in approximately 20% of these patients. The global incidence of leukemia is much higher than in the general pediatric population. Among these, acute megakaryoblastic leukemia has special characteristics in this population group and generally has a good prognosis, with a treatment that is less intense than in other children without trisomy. Lymphoblastic leukemia, however, may have a worse prognosis than that of children without constitutional chromosomal disorder. A less described aspect is that regarding the benign conditions and the characteristics of the 3 hematopoietic lines frequently found in DS." @default.
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- W84202379 date "2012-01-01" @default.
- W84202379 modified "2023-09-26" @default.
- W84202379 title "Alteraciones hematológicas en las personas con síndrome de Down" @default.
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